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Nanomedicine in treatment of breast cancer - A challenge to conventional therapy.
Seminars in Cancer Biology ( IF 14.5 ) Pub Date : 2019-12-20 , DOI: 10.1016/j.semcancer.2019.12.016
Muhammad Afzal 1 , Ameeduzzafar 1 , Khalid Saad Alharbi 1 , Nabil K Alruwaili 1 , Fahad A Al-Abassi 2 , Abdulrahman Al Labeed Al-Malki 2 , Imran Kazmi 2 , Vikas Kumar 3 , Mohammad Amjad Kamal 4 , Muhammad Shahid Nadeem 2 , Muhammad Aslam 5 , Firoz Anwar 2
Affiliation  

Amongst the various types of cancer, breast cancer is a highly heterogeneous disease and known as the leading cause of death among women globally. The extensive interdisciplinary investigation in nanotechnology and cancer biomedical research has been evolved over the years for its effective treatment. However, the advent of chemotherapeutic resistance in breast cancer is one of the major confront researchers are facing in achieving successful chemotherapy. Research in the area of cancer nanotechnology over the years have now been revolutionized through the development of smart polymers, lipids, inorganic materials and eventually their surface-engineering with targeting ligands. Moreover, nanotechnology further extended and brings in the notice the new theranostic approach which combining the therapy and imaging simultaneously. Currently, research is being envisaged in the area of novel nano-pharmaceutical design viz. liposome, nanotubes, polymer lipid hybrid system, which focuses to make the chemotherapy curative and long-lasting. In this review, we aimed to discuss the recent advancement of different surface-engineered/targeted nanomedicines that improved the drug efficacy in breast cancer.

中文翻译:

治疗乳腺癌的纳米药物——对传统疗法的挑战。

在各种类型的癌症中,乳腺癌是一种高度异质性的疾病,被称为全球女性死亡的主要原因。多年来,纳米技术和癌症生物医学研究的广泛跨学科研究已经发展为有效治疗。然而,乳腺癌化疗耐药的出现是研究人员在实现成功化疗方面面临的主要挑战之一。多年来,癌症纳米技术领域的研究已经通过智能聚合物、脂质、无机材料的开发以及最终使用靶向配体的表面工程而发生了革命性的变化。此外,纳米技术进一步扩展并引入了将治疗和成像同时结合的新治疗诊断方法。现在,正在设想在新型纳米药物设计领域进行研究,即。脂质体、纳米管、聚合物脂质混合系统,重点使化疗具有疗效和持久性。在这篇综述中,我们旨在讨论不同表面工程/靶向纳米药物的最新进展,这些药物提高了乳腺癌的药物疗效。
更新日期:2019-12-20
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