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Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis.
PLOS Neglected Tropical Diseases ( IF 3.8 ) Pub Date : 2019-12-19 , DOI: 10.1371/journal.pntd.0007809 Ali Rostami 1, 2 , Seyed Mohammad Riahi 3 , Celia V Holland 4 , Ali Taghipour 5 , Mohsen Khalili-Fomeshi 6 , Yadolah Fakhri 7 , Vahid Fallah Omrani 8 , Peter J Hotez 9, 10 , Robin B Gasser 11
PLOS Neglected Tropical Diseases ( IF 3.8 ) Pub Date : 2019-12-19 , DOI: 10.1371/journal.pntd.0007809 Ali Rostami 1, 2 , Seyed Mohammad Riahi 3 , Celia V Holland 4 , Ali Taghipour 5 , Mohsen Khalili-Fomeshi 6 , Yadolah Fakhri 7 , Vahid Fallah Omrani 8 , Peter J Hotez 9, 10 , Robin B Gasser 11
Affiliation
BACKGROUND
Human toxocariasis is an important neglected disease. We performed a systematic review and meta-analysis study to estimate the global and regional prevalence of anti-Toxocara serum antibodies (referred to as 'T-seroprevalence') in human populations around the world.
METHODS
We searched five international databases (PubMed, EMBASE, Web of Science, SciELO and Scopus) for seroprevalence studies published from 1 January 1980 to 15 March 2019. We used random effect models to calculate the overall T-seroprevalence (with 95% CIs) in all six WHO regions and worldwide. We also conducted subgroup and linear meta-regression analyses to evaluate the impact of socio-demographic, geographical and climatic parameters on seroprevalence.
RESULTS
We identified 250 eligible studies (253 datasets) comprising 265,327 participants in 71 countries for inclusion in the present meta-analysis. The estimated global T-seroprevalence rate was 19.0% (95%CI, 16.6-21.4%; 62,927/265,327); seroprevalence was highest in the African region (37.7%; 25.7-50.6%) and lowest in the Eastern Mediterranean region (8.2%; 5.1-12.0%). The pooled seroprevalence for other WHO regions was 34.1% (20.2-49.4%) in the South-East Asia; 24.2% (16.0-33.5%) in the Western Pacific; 22.8% (19.7-26.0%) in the American; and 10.5% (8.5-12.8%) in the European regions. A significantly higher T-seroprevalence was associated with a lower income level; lower human development index (HDI); lower latitude; higher humidity; higher temperature; and higher precipitation (P-value < 0.001). Potential risk factors associated with seropositivity to Toxocara included male gender; living in a rural area; young age; close contact with dogs, cats or soil; consumption of raw meat; and the drinking of untreated water.
CONCLUSIONS
The present findings indicate high levels of infection with, or exposure to Toxocara spp. in many countries, which calls for increased attention to human toxocariasis and improved measures to prevent adverse health risks of this disease.
中文翻译:
全世界人群弓形虫病的血清流行率估计:系统评价和荟萃分析。
背景技术人类弓形虫病是一种重要的被忽视的疾病。我们进行了系统的综述和荟萃分析研究,以评估全球人群中抗弓形虫血清抗体(称为“ T血清流行性”)的全球和区域患病率。方法我们搜索了五个国际数据库(PubMed,EMBASE,Web of Science,SciELO和Scopus)进行1980年1月1日至2019年3月15日发布的血清阳性率研究。我们使用随机效应模型来计算总体T血清阳性率(CI值为95%)在世卫组织所有六个区域以及全世界范围内。我们还进行了亚组和线性元回归分析,以评估社会人口统计学,地理和气候参数对血清阳性率的影响。结果我们确定了250项合格研究(253个数据集),其中包括265项,来自71个国家/地区的327名参与者参加了本荟萃分析。估计的全球T血清患病率是19.0%(95%CI,16.6-21.4%; 62,927 / 265,327); 血清阳性率在非洲地区最高(37.7%; 25.7-50.6%),在东地中海地区最低(8.2%; 5.1-12.0%)。东南亚其他地区的总血清阳性率是34.1%(20.2-49.4%);西太平洋地区24.2%(16.0-33.5%);美国人为22.8%(19.7-26.0%);和欧洲地区的10.5%(8.5-12.8%)。T血清阳性率显着升高与较低的收入水平相关;较低的人类发展指数(HDI);低纬度;湿度较高;更高的温度 和更高的降水量(P值<0.001)。与弓形虫血清反应阳性相关的潜在危险因素包括男性;生活在农村地区;年轻的时候; 与狗,猫或土壤紧密接触;食用生肉;以及饮用未经处理的水。结论目前的发现表明高水平的弓形虫感染或暴露。在许多国家,这要求人们更加关注人类弓形虫病,并采取改进措施来预防这种疾病的不利健康风险。
更新日期:2019-12-20
中文翻译:
全世界人群弓形虫病的血清流行率估计:系统评价和荟萃分析。
背景技术人类弓形虫病是一种重要的被忽视的疾病。我们进行了系统的综述和荟萃分析研究,以评估全球人群中抗弓形虫血清抗体(称为“ T血清流行性”)的全球和区域患病率。方法我们搜索了五个国际数据库(PubMed,EMBASE,Web of Science,SciELO和Scopus)进行1980年1月1日至2019年3月15日发布的血清阳性率研究。我们使用随机效应模型来计算总体T血清阳性率(CI值为95%)在世卫组织所有六个区域以及全世界范围内。我们还进行了亚组和线性元回归分析,以评估社会人口统计学,地理和气候参数对血清阳性率的影响。结果我们确定了250项合格研究(253个数据集),其中包括265项,来自71个国家/地区的327名参与者参加了本荟萃分析。估计的全球T血清患病率是19.0%(95%CI,16.6-21.4%; 62,927 / 265,327); 血清阳性率在非洲地区最高(37.7%; 25.7-50.6%),在东地中海地区最低(8.2%; 5.1-12.0%)。东南亚其他地区的总血清阳性率是34.1%(20.2-49.4%);西太平洋地区24.2%(16.0-33.5%);美国人为22.8%(19.7-26.0%);和欧洲地区的10.5%(8.5-12.8%)。T血清阳性率显着升高与较低的收入水平相关;较低的人类发展指数(HDI);低纬度;湿度较高;更高的温度 和更高的降水量(P值<0.001)。与弓形虫血清反应阳性相关的潜在危险因素包括男性;生活在农村地区;年轻的时候; 与狗,猫或土壤紧密接触;食用生肉;以及饮用未经处理的水。结论目前的发现表明高水平的弓形虫感染或暴露。在许多国家,这要求人们更加关注人类弓形虫病,并采取改进措施来预防这种疾病的不利健康风险。