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Quantitative simultaneous determination of pentoxifylline and paracetamol in drug and biological samples at graphene nanoflakes modified electrode
Journal of the Taiwan Institute of Chemical Engineers ( IF 5.7 ) Pub Date : 2019-12-20 , DOI: 10.1016/j.jtice.2019.11.011
S. Meenakshi , K. Pandian , S.C.B. Gopinath

Simultaneous voltammetry determination of pentoxifylline (PTX) and paracetamol (PAR) were investigated by using graphene nanoflakes modified glassy carbon electrode (GrNF/GCE) in drug and biological samples. The synthesized flake was characterized using various analytical methods and the electron transfer behavior of GrNF was confirmed by CV and EIS techniques. Electrocatalytic oxidation of PTX and PAR at GrNF/GCE occurred at a potential of +1.220 V and + 0.190 V. The peak to peak separation (900 mV) was obtained for PTX and PAR at GrNF/GCE using DPV method. Amperometry technique was carried out to measure the current response of PTX and PAR and its dynamic ranges from 0.2 × 10−8–300 × 10−6 M (0.9938) and 0.1 × 10−8–150 × 10−6 M (0.9982). The LOD of PTX and PAR were determined to be 0.75 and 0.43 nM (S/N = 3), respectively. This system provides high-level sensitivity in the presence of an excess concentration of easily oxidizable interfering biological molecules and it shows a better reproducibility and repeatability. The present system has been effectively applied for the PTX and PAR determination in real samples.



中文翻译:

石墨烯纳米薄片修饰电极同时定量测定药物和生物样品中己酮可可碱和扑热息痛

采用石墨烯纳米薄片修饰的玻碳电极(GrNF / GCE),同时测定了己酮可可碱(PTX)和扑热息痛(PAR)的伏安法。使用各种分析方法对合成的薄片进行了表征,并通过CV和EIS技术证实了GrNF的电子转移行为。在GrNF / GCE上,PTX和PAR在+1.220 V和+ 0.190 V的电催化下发生氧化。使用DPV方法,在GrNF / GCE上,PTX和PAR达到峰-峰分离(900 mV)。进行电流分析技术来测量PTX和PAR的电流响应,其动态范围为0.2×10 -8 –300×10 -6  M(0.9938)和0.1×10 -8 –150×10 -6 M(0.9982)。PTX和PAR的LOD分别确定为0.75和0.43 nM(S / N = 3)。在过量浓度的易氧化干扰生物分子存在下,该系统可提供高水平的灵敏度,并且显示出更好的重现性和可重复性。本系统已经有效地应用于实际样品中PTX和PAR的测定。

更新日期:2019-12-20
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