Context: Alcoholic liver cirrhosis is a significant risk factor for the development of hepatocellular carcinoma (HCC). The importance of tumour-associated cirrhosis in the development or progression of HCC is not understood. MiRNAs are important regulators for HCC development, but their role in HCC due to alcoholic liver cirrhosis is unclear.Objective: The aim of this study is the detection of miRNA expression in alcoholic liver cirrhosis, tumour-associated cirrhosis, and HCC.Materials and methods: We analysed the differences in the miRNA profiles of HCC, tumour-associated cirrhosis, and cirrhosis without HCC samples from 30 patients who underwent liver transplantation because of alcoholic liver disease.Results: Microarray analyses revealed 40 significantly differentially expressed miRNAs between HCC tissue and tumour-associated cirrhosis tissue. Furthermore, the microarray analysis discovered 56 differentially expressed miRNAs in tumour-associated cirrhosis and cirrhosis without HCC.Discussion: The differences of miRNA profile in alcoholic liver cirrhosis with and without HCC could improve understanding of HCC development, as well as lead to a new diagnostic tool in HCC screening.Conclusion: We were able to show for the first time, the differences of miRNA profile as promising biomarker in HCC, tumour-associated cirrhosis, and cirrhosis without HCC in context of alcoholic liver disease.

中文翻译：

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酒精性肝硬化中基于组织的miRNA定位：有或没有肝细胞癌的肝硬化患者的不同情况。

背景：酒精性肝硬化是肝细胞癌（HCC）发生的重要危险因素。尚不了解肿瘤相关性肝硬化在肝癌发生或发展中的重要性。miRNA是肝癌发展的重要调控因子，但尚不清楚其在酒精性肝硬化引起的HCC中的作用。目的：本研究的目的是检测酒精性肝硬化，肿瘤相关性肝硬化和HCC中miRNA的表达。 ：我们分析了30例因酒精性肝病而接受肝移植的患者的HCC，肿瘤相关性肝硬化和无HCC肝硬化的miRNA谱图的差异。结果：微阵列分析显示，HCC组织与肿瘤之间存在40个显着差异表达的miRNA。 -相关的肝硬化组织。