Mesenchymal stem cells (MSCs) have putative roles in maintaining adult tissue health, and the functional decline of MSCs has emerged as a crucial pathophysiological driver of various diseases. Epigenetic regulation is essential for establishing and preserving MSC homeostasis in vivo. Furthermore, growing evidence suggests that epigenetic dysregulation contributes to age- and disease-associated MSC alterations. Epigenetic marks in MSCs can be amplified through self-renewal divisions and transmitted to differentiated progeny, further perpetuating their role in tissue maintenance and pathogenesis. We review the epigenetic regulation of MSC homeostasis, emphasizing its contributions to organismal health and disease. Understanding these epigenetic mechanisms could hold promise as targets for MSC-mediated regenerative therapies.

中文翻译：

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间充质干细胞稳态的表观遗传调控。

间充质干细胞（MSCs）在维持成人组织健康中具有假定的作用，并且MSCs的功能下降已成为各种疾病的关键病理生理驱动因素。表观遗传调控对于体内建立和保持MSC稳态至关重要。此外，越来越多的证据表明，表观遗传失调导致了年龄和疾病相关的MSC改变。MSC中的表观遗传标记可以通过自我更新分裂进行扩增，并传播至分化的后代，从而进一步使其在组织维持和发病机理中的作用得以延续。我们回顾了MSC稳态的表观遗传调控，强调其对机体健康和疾病的贡献。了解这些表观遗传机制可能有望作为MSC介导的再生疗法的目标。