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Opioid Receptor Blockade Inhibits Self-Disclosure During a Closeness-Building Social Interaction
Psychoneuroendocrinology ( IF 3.7 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.psyneuen.2019.104559 Kristina Tchalova 1 , Geoff MacDonald 2
Psychoneuroendocrinology ( IF 3.7 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.psyneuen.2019.104559 Kristina Tchalova 1 , Geoff MacDonald 2
Affiliation
Social ties are critical to human health and well-being; thus, it is important to gain a better understanding of the neurobiological mechanisms involved in the development of interpersonal closeness. Prior research indicates that endogenous opioids may play a role in social affiliation by elaborating feelings of social connection and warmth; however, it is not currently known whether opioids mediate affiliative behavior and emerging feelings of closeness in humans at the relationship initiation stage. This randomized, double-blind study examined opioidergic processes in the context of a naturalistic, face-to-face social interaction. Eighty pairs of unacquainted participants (final N = 159 due to removal of one dyad member from analysis) received either 50 mg of the opioid receptor antagonist naltrexone or placebo prior to completing a closeness-building exercise centered on escalating self-disclosure (sharing of personal information about the self). Compared to the placebo group, naltrexone participants held lower social reward expectations prior to the interaction, engaged in less intimacy-fostering behavior (self-disclosure) during the interaction, and reported wanting less closeness with their partner. Feelings of social connection were not significantly lower in the naltrexone group. However, placebo participants experienced improvements in mood after the closeness-building task whereas naltrexone participants did not. These findings suggest that endogenous opioids may contribute to behavioral, affective, and motivational processes related to the development of initial closeness.
中文翻译:
阿片受体阻断在建立亲密的社交互动中抑制自我披露
社会关系对人类健康和福祉至关重要;因此,重要的是要更好地了解人际亲密关系发展中涉及的神经生物学机制。先前的研究表明,内源性阿片类药物可能通过阐述社会联系和温暖的感觉在社会归属中发挥作用;然而,目前尚不清楚阿片类药物是否会在关系开始阶段调节人类的亲和行为和新出现的亲近感。这项随机、双盲研究在自然主义的、面对面的社交互动的背景下检查了阿片类药物的过程。80 对不认识的参与者(最终 N = 159,因为从分析中去除了一个二元组成员)在完成以不断升级的自我披露(分享个人信息)为中心的建立亲密关系之前接受了 50 毫克阿片受体拮抗剂纳曲酮或安慰剂。关于自己的信息)。与安慰剂组相比,纳曲酮参与者在互动前对社会奖励的期望较低,在互动期间参与较少的亲密行为(自我表露),并报告希望与他们的伴侣不那么亲密。纳曲酮组的社会联系感并没有显着降低。然而,安慰剂参与者在建立亲密关系后情绪有所改善,而纳曲酮参与者则没有。
更新日期:2020-03-01
中文翻译:
阿片受体阻断在建立亲密的社交互动中抑制自我披露
社会关系对人类健康和福祉至关重要;因此,重要的是要更好地了解人际亲密关系发展中涉及的神经生物学机制。先前的研究表明,内源性阿片类药物可能通过阐述社会联系和温暖的感觉在社会归属中发挥作用;然而,目前尚不清楚阿片类药物是否会在关系开始阶段调节人类的亲和行为和新出现的亲近感。这项随机、双盲研究在自然主义的、面对面的社交互动的背景下检查了阿片类药物的过程。80 对不认识的参与者(最终 N = 159,因为从分析中去除了一个二元组成员)在完成以不断升级的自我披露(分享个人信息)为中心的建立亲密关系之前接受了 50 毫克阿片受体拮抗剂纳曲酮或安慰剂。关于自己的信息)。与安慰剂组相比,纳曲酮参与者在互动前对社会奖励的期望较低,在互动期间参与较少的亲密行为(自我表露),并报告希望与他们的伴侣不那么亲密。纳曲酮组的社会联系感并没有显着降低。然而,安慰剂参与者在建立亲密关系后情绪有所改善,而纳曲酮参与者则没有。