Non-specific interactions play a major role in the microscale functioning of biological units. Exploiting these interactions in design and application of biomedical systems has been beneficial in different branches of biomedicine. In this review, recently designed biomedical systems that function mainly, or partially, based on non-specific interactions, including but not limited to electrostatic, hydrophobic, and steric interactions, are discussed. The focus will be on the application of these interactions in biolubrication, bioadhesion and antifouling, drug delivery and tissue engineering. The information gathered in this review can be helpful in guiding the readers in the direction that the field has been following in the past few years.

非特异性相互作用在生物单位的微观功能中起主要作用。在生物医学系统的设计和应用中利用这些相互作用在生物医学的不同分支中是有益的。在这篇综述中，讨论了最近设计的生物医学系统，该系统主要或部分地基于非特异性相互作用，包括但不限于静电，疏水和空间相互作用。重点将放在这些相互作用在生物润滑，生物粘附和防污，药物输送和组织工程中的应用。这篇综述中收集的信息可以帮助指导读者朝着该领域在过去几年中一直遵循的方向发展。