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Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia.
BMC Gastroenterology ( IF 2.4 ) Pub Date : 2019-12-19 , DOI: 10.1186/s12876-019-1133-7
Haitao Shi 1 , Shanshan Zhu 1, 2 , Bin Qin 1 , Lianli Wang 1 , Juan Yang 3 , Guolong Lu 1 , Fei Dai 1
Affiliation  

BACKGROUND Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity and gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD). This study aimed to investigate the expression of NGF, its high affinity receptor tropomyosin receptor kinase A (TrkA) and the EGC activation marker glial fibrillary acidic protein (GFAP) in the gastric mucosa of patients with FD and the association of these proteins with dyspeptic symptoms. METHODS Gastric mucosal biopsies taken from 27 FD patients (9 epigastric pain syndrome (EPS) patients, 7 postprandial distress syndrome (PDS) patients and 11 EPS overlap PDS patients) and 26 control subjects were used for analysis. The expression of NGF, TrkA and GFAP was examined, and the association of these proteins with dyspeptic symptoms, including epigastric pain, postprandial fullness, early satiation and epigastric burning, was analysed. RESULTS The expression levels of NGF, TrkA, and GFAP in the gastric mucosa were significantly higher in the EPS group, the PDS group, and the EPS overlap PDS group than in the healthy control group. There was no significant difference between the FD subgroups. TrkA colocalized with GFAP, which indicated that TrkA was localized to EGCs, and the expression of TrkA in EGCs was significantly higher in the FD group than in the control group. Changes in the expression of NGF, TrkA, and GFAP were positively correlated with epigastric pain, postprandial fullness and early satiation but had no significant relationship with epigastric burning. CONCLUSIONS The increased expression of gastric NGF, TrkA and GFAP might be involved in FD pathophysiology and symptom perception.

中文翻译:

功能性消化不良患者的胃黏膜中神经生长因子和Tropomyosin受体激酶A增加。

背景技术神经生长因子(NGF)和肠神经胶质细胞(EGCs)与内脏超敏反应和胃肠道蠕动障碍有关,可能代表功能性消化不良(FD)的发病机理。这项研究旨在调查NGF,其高亲和力受体原肌球蛋白受体激酶A(TrkA)和EGC激活标记物胶质纤维酸性蛋白(GFAP)在FD患者胃黏膜中的表达以及这些蛋白与消化不良症状的关系。方法采用27例FD患者(9例胃上痛综合征(EPS),7例餐后窘迫综合征(PDS)和11例EPS重叠PDS患者)和26例对照受试者进行胃黏膜活检。检查了NGF,TrkA和GFAP的表达,以及这些蛋白质与消化不良症状的相关性,分析包括上腹痛,餐后饱胀,早期饱食和上腹灼痛。结果EPS组,PDS组和EPS重叠PDS组胃黏膜中NGF,TrkA和GFAP的表达水平明显高于健康对照组。FD亚组之间无显着差异。TrkA与GFAP共定位,表明TrkA定位于EGCs,FD组中Erks中TrkA的表达明显高于对照组。NGF,TrkA和GFAP的表达变化与上腹痛,餐后饱胀和早期饱食呈正相关,但与上腹烧灼无明显关系。结论胃NGF的表达增加,
更新日期:2019-12-20
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