Journal of Flow Chemistry ( IF 2.7 ) Pub Date : 2019-12-20 , DOI: 10.1007/s41981-019-00054-9 Claire Empel , Rene M. Koenigs
Photochemistry constitutes an important tool to conduct environmentally benign and efficient transformations in organic synthesis. Conventional batch transformations are limited in productivity and scale due to Beer’s law, which can be easily overcome using flow chemistry approaches. Herein, we report on the continuous-flow photolysis of aryl diazoacetates using a glass microreactor and blue LEDs. Following this methodology, we were able to demonstrate the application of continuous-flow chemistry in photochemical cyclopropanation and rearrangement reactions and demonstrate the scalability of photochemical carbene transfer reactions.
中文翻译:
连续流光化学卡宾转移反应
光化学是在有机合成中进行环境友好和有效转化的重要工具。由于比尔定律,传统的批量转换在生产率和规模上受到限制,可以使用流化学方法轻松克服这些定律。在本文中,我们报道了使用玻璃微反应器和蓝色LED进行的芳基重氮乙酸酯的连续流光解。按照这种方法,我们能够证明连续流化学在光化学环丙烷化和重排反应中的应用,并证明了光化学卡宾转移反应的可扩展性。