Abstract In order to study the solubility of the formed solute in the reaction solvent, the solubility of propacetamol hydrochloride (PRO) in pure and mixed solvents was experimentally determined at T = 273.15–313.15 K. In all selected pure solvents, the solubility data form high to low was followed by the sequence: methanol > ethanol > acetone > n-propanol > isopropanol > acetonitrile. In mixture of (acetone + ethanol), the solubility decreased monotonically with the increasing mass fraction of acetone in mixed solvents at a certain temperature. The properties of solvents and the interaction between solvents and solutes were analyzed. All RAD values in the modified Apelblat equation are less than those in λh equation. Therefore, modified Apelblat is more suitable for correlating the solubility data of PRO in selected pure solvents. In addition, satisfactory correlation results in (acetone + ethanol) were obtained by Jouyban-Acree model. The values of Δ H ° sol and Δ S ° sol are all positive in this experiment, which indicates the dissolution process is not only endothermic but also entropy-driving. Moreover, the values of % ξ H are greater than those of % ξ TS , which indicates the enthalpy is the main contributor to the change of standard Gibbs energy during the dissolution process of PRO.

中文翻译：

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盐酸丙乙酰氨基酚在纯溶剂和混合溶剂中的溶解行为及表观热力学分析

摘要 为了研究形成的溶质在反应溶剂中的溶解度，实验测定了盐酸丙乙酰氨基酚 (PRO) 在纯溶剂和混合溶剂中的溶解度，T = 273.15–313.15 K。在所有选定的纯溶剂中，溶解度数据形成从高到低依次为：甲醇>乙醇>丙酮>正丙醇>异丙醇>乙腈。在（丙酮+乙醇）的混合物中，在一定温度下，随着丙酮在混合溶剂中质量分数的增加，溶解度单调下降。分析了溶剂的性质以及溶剂与溶质之间的相互作用。修改后的 Apelblat 方程中的所有 RAD 值都小于 λh 方程中的值。因此，改进的 Apelblat 更适合关联 PRO 在选定纯溶剂中的溶解度数据。此外，Jouyban-Acree 模型在（丙酮+乙醇）中获得了令人满意的相关结果。本实验中ΔH°溶胶和ΔS°溶胶均为正值，说明溶解过程不仅是吸热的，而且是熵驱动的。此外，% ξ H 的值大于% ξ TS 的值，这表明在PRO的溶解过程中，焓是标准吉布斯能变化的主要贡献者。