Powdered milk and its derivatives are widely consumed worldwide, which require the development of reference materials for the evaluation of analytical methodologies that are developed for the analysis of these samples. In this work, the homogeneity and stability of a powdered milk laboratory reference material candidate were evaluated using chemometric tools as an alternative to analysis of variance (ANOVA). Elements Ca, Fe, K, Mg, P, Na and Zn were quantified by inductively coupled plasma optical emission spectrometry (ICP OES) after the acid digestion procedure using microwave-assisted radiation. The results obtained through not only ANOVA, but also PCA and HCA allow us to state that the material can be considered homogeneous and stable. However, the application of the chemometric tools (PCA and HCA) allowed the extraction of more information compared to ANOVA, besides confirming the homogeneity and stability of the powdered milk laboratory reference material candidate.

中文翻译：

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化学计量学工具在制备用于无机分析的奶粉实验室参考材料过程中的均质性和稳定性评估中的应用

奶粉及其衍生物在世界范围内广泛消费，这就需要开发参考材料来评估分析这些样品的分析方法。在这项工作中，使用化学计量学工具（作为方差分析（ANOVA）的替代方法）评估了奶粉实验室参考材料候选物的均质性和稳定性。在使用微波辅助辐射进行酸消解后，通过电感耦合等离子体发射光谱法（ICP OES）对元素Ca，Fe，K，Mg，P，Na和Zn进行定量。通过ANOVA以及PCA和HCA所获得的结果使我们可以说该材料可以被认为是均匀且稳定的。然而，