Generation of short peptides with a single β-strand structure in solution is difficult. Herein, we design a new class of single β-strand peptidic mimics that are stable without self-aggregation in protic and non-protic solvents. Introduction of one present β-strand mimic can induce and propagate the β-strand structure for at least a penta-peptide sequence.

中文翻译：

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基于肽的短单β链模拟物，没有氢键或聚集。

在溶液中难以产生具有单个β链结构的短肽。在本文中，我们设计了一类新型的单链β-肽模拟物，该模拟物在质子和非质子溶剂中稳定而不会自聚集。引入一种当前的β-链模拟物可以诱导和传播至少五肽序列的β-链结构。