An iodine promoted cascade cycloisomerization of 1-en-6,11-diynes is presented for the easy preparation of tetrahydrobenzo[f]isoquinolines. This developed reaction system is identified as having good functional-group applicability and can be scaled up to gram quantities. In this transformation, two new cyclic frameworks and one carbonyl group are formed with four new bonds constructed. Additionally, the resulting iodo-substituted compounds could be further derived through simple elimination reactions.

中文翻译：

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碘促进了1-en-6,11-二炔的级联环异构化。

为了容易制备四氢苯并[f]异喹啉，提出了碘促进的1-en-6,11-二炔级联环异构化反应。该发达的反应系统被认为具有良好的官能团适用性，并且可以按比例放大至克量。在这种转化中，形成了两个新的环状骨架和一个羰基，并构建了四个新的键。另外，所得的碘取代的化合物可以通过简单的消除反应进一步得到。