Although pre‐exposure prophylaxis (PrEP.) is an efficacious HIV prevention strategy, its preventive benefit has not been shown among young women in sub‐Saharan Africa, likely due to non‐adherence. Adherence may be improved with the use of injectable long‐acting PrEP methods currently being developed. We hypothesize that providing long‐acting PrEP to women using injectable contraceptives, the most frequently used contraceptive method in South Africa, could improve adherence to PrEP, result in a reduction of new HIV infections, and be a relatively easy‐to‐reach target population. In this modelling study, we assessed the epidemiological impact and cost‐effectiveness of providing long‐acting PrEP to injectable contraceptive users in Limpopo, South Africa.

中文翻译：

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为南非注射避孕药使用者提供长效暴露前预防以预防艾滋病毒的流行病学影响和成本效益：一项模型研究

尽管暴露前预防 (PrEP.) 是一种有效的艾滋病毒预防策略，但其预防益处尚未在撒哈拉以南非洲的年轻女性中显示出来，这可能是由于不遵守规定。使用目前正在开发的可注射长效 PrEP 方法可以提高依从性。我们假设，为使用注射避孕药（南非最常用的避孕方法）的女性提供长效 PrEP，可以提高 PrEP 的依从性，减少新发 HIV 感染，并成为相对容易接触到的目标人群。在这项建模研究中，我们评估了向南非林波波省注射避孕药使用者提供长效 PrEP 的流行病学影响和成本效益。