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Effects of the microalgae Chlamydomonas on gastrointestinal health
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2019-12-19 , DOI: 10.1016/j.jff.2019.103738
Francis J. Fields , Franck Lejzerowicz , Dave Schroeder , Soo M. Ngoi , Miller Tran , Daniel McDonald , Lingjing Jiang , John T. Chang , Rob Knight , Stephen Mayfield

The effects of consuming whole-cell biomass of the green algae Chlamydomonas reinhardtii on gastrointestinal health in mice and humans was examined. A 14-day murine model of acute colitis revealed significantly less weight loss in mice that received C. reinhardtii biomass by oral gavage. Based on this result, human volunteers with varying gastrointestinal symptoms were asked to consume 1 or 3 g of C. reinhardtii daily for 30 days. Participants reported changes in their gastrointestinal health through a questionnaire and provided stool samples to analyze the composition of their gut microbiome. Those who typically experience frequent gastrointestinal symptoms reported significantly less bowel discomfort or diarrhea, significantly less gas or bloating, more regular bowel movements, and better stool consistency when regularly consuming C. reinhardtii. Analysis of participant stool samples suggested the gut microbiome composition in all groups remained complex, and no signs of dysbiosis or adverse effect on microbial composition were observed.



中文翻译:

微藻衣藻对胃肠道健康的影响

检查了食用绿藻莱茵衣藻全细胞生物量对小鼠和人类胃肠道健康的影响。一个为期14天的急性结肠炎小鼠模型显示,通过口服管饲法喂食了莱茵衣藻生物量的小鼠,体重减轻显着减少。根据此结果,要求具有不同胃肠道症状的人类志愿者食用1或3克赖因氏梭菌。每天30天。参与者通过问卷报告了其胃肠道健康的变化,并提供了粪便样本以分析其肠道微生物组的组成。那些经常出现胃肠道症状的人报告说,经常食用驯鹿茶时,肠不适或腹泻明显减少,气体或腹胀明显减少,排便规律性更高,大便稠度也更好。对参与者粪便样本的分析表明,所有组中的肠道微生物组组成均保持复杂,没有观察到菌丝异常或对微生物组成产生不利影响的迹象。

更新日期:2019-12-19
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