As a key mediator of efficacy and toxicity, the linker connecting the payload in antibody drug conjugates determines cellular distribution and payload release. Sorkin et al. (2019) have created novel fluorescence-based linkers to quantify the rate of intracellular bond cleavage and track live-cell kinetics for designing more effective agents.

中文翻译：

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切断联系：量化抗体药物偶联物的有效载荷释放。

作为功​​效和毒性的关键介质，连接抗体药物偶联物中有效载荷的接头决定了细胞分布和有效载荷释放。索金等人。（2019 年）创建了新的基于荧光的接头，以量化细胞内键断裂的速率并跟踪活细胞动力学以设计更有效的试剂。