There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in patients identified using the 'ultra high risk' (UHR) for psychosis approach. The current study investigated whether basic symptoms, specifically cognitive disturbances (COGDIS), were associated with a greater risk of transition to psychotic disorder and persistent attenuated psychotic symptoms (APS) at medium term follow-up (mean = 3.4 years) in UHR patients, as well as with general psychopathology at baseline. The sample included 304 UHR participants (mean age = 19.12 years) involved in an international multicenter trial of omega-3 fatty acids. UHR individuals who also met the COGDIS criteria (basic symptoms risk criteria) did not have a greater risk of transition than those who met the UHR criteria alone. However, meeting COGDIS risk criteria was associated with a greater likelihood of meeting the UHR attenuated psychotic symptoms risk group (i.e., having persistent attenuated psychotic symptoms) at 12-month follow-up (odds ratio = 1.85; 95% CI = 1.03, 3.32). Greater severity of cognitive basic symptoms was also independently associated with more severe general psychopathology at study entry. The findings do not support the notion that combined risk identification approaches (UHR and basic symptoms) aid in the identification of individuals at greatest risk of psychosis, although this interpretation is limited by the modest transition to psychosis rate (13%) and the time of follow up. However, the findings indicate that basic symptoms may be a clinically useful marker of more severe general psychopathology in UHR groups and risk for persistent attenuated psychotic symptoms.

中文翻译：

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青少年精神病超高危人群的基本症状：与临床特征和结局的关联

对于使用“超高风险”(UHR) 精神病方法确定的患者，基本症状的预测价值及其与其他精神病理学的关系的研究有限。目前的研究调查了基本症状，特别是认知障碍 (COGDIS)，是否与 UHR 患者在中期随访中（平均 = 3.4 年）转变为精神病性障碍和持续性弱化精神病性症状 (APS) 的风险更大有关，以及基线时的一般精神病理学。样本包括 304 名参与 omega-3 脂肪酸国际多中心试验的 UHR 参与者（平均年龄 = 19.12 岁）。同时满足 COGDIS 标准（基本症状风险标准）的 UHR 个体与仅满足 UHR 标准的个体相比，没有更大的转变风险。然而，在 12 个月的随访中，满足 COGDIS 风险标准与满足 UHR 减弱的精神病症状风险组（即具有持续减弱的精神病症状）的可能性更大相关（优势比 = 1.85；95% CI = 1.03, 3.32 ）。认知基本症状的更严重程度也与研究开始时更严重的一般精神病理学独立相关。研究结果不支持组合风险识别方法（UHR 和基本症状）有助于识别精神病风险最大的个体的观点，尽管这种解释受到向精神病的适度过渡（13%）和时间的限制。跟进。然而，