The adrenocorticotropic hormone (ACTH) receptor, known as the melanocortin-2 receptor (MC2R), plays a key role in regulating adrenocortical function. ACTH receptor is a subtype of the melanocortin receptor family which is a member of the G-protein coupled receptor (GPCR) superfamily. ACTH receptor has unique characteristics among MCRs. α-MSH, β-MSH, γ-MSH and ACTH are agonists for MCRs but only ACTH is the agonist for ACTH receptor. In addition, the melanocortin receptor accessory protein (MRAP) is required for ACTH receptor expression at cell surface and function. In this review, we summarized the information available on the relationship between ACTH and ACTH receptor and provide the latest understanding of the molecular basis of the ACTH receptor responsible for ligand selectivity and function.

中文翻译：

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ACTH受体对配体选择性的分子决定因素。

促肾上腺皮质激素（ACTH）受体，称为黑皮质素2受体（MC2R），在调节肾上腺皮质功能中起关键作用。ACTH受体是黑皮质素受体家族的亚型，它是G蛋白偶联受体（GPCR）超家族的成员。ACTH受体在MCR中具有独特的特征。α-MSH，β-MSH，γ-MSH和ACTH是MCR的激动剂，但只有ACTH是ACTH受体的激动剂。另外，黑素皮质素受体辅助蛋白（MRAP）是ACTH受体在细胞表面和功能上表达所必需的。在这篇综述中，我们总结了有关ACTH和ACTH受体之间关系的可用信息，并提供了对负责配体选择性和功能的ACTH受体分子基础的最新理解。