Peptides constituted of backbone homologated α-amino acids combined with carbon materials offer interesting possibilities in the modulation of cellular functions. In this work, we have prepared diphenylalanine β- and γ-peptides and conjugated them to carbon nanotubes (CNTs). These hybrids were able to self-assemble into fibrillar dendritic structures enabling the growth of primary hippocampal cells and the modulation of their neuronal functions. In particular, following the deposition of the different nanomaterials on glass substrates, we have evaluated their effects on circuit function and geometry. The geometrical restrictions due to CNT nucleated nodes allowed growth of neuronal networks with control over network geometry, and exploring its functional impact. In diverse applications from basic neuroscience, the presence of CNT nodes may be exploited in brain interfaces able to convey highly localized electrical stimuli.

中文翻译：

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由纳米管和骨架改变的二肽制成的混合接口调整神经元网络架构。

由与碳材料结合的骨架同源α-氨基酸构成的肽在调节细胞功能方面提供了有趣的可能性。在这项工作中，我们制备了二苯丙氨酸 β 和 γ 肽并将它们与碳纳米管 (CNT) 结合。这些杂种能够自组装成纤维状树突结构，从而使原代海马细胞能够生长并调节其神经元功能。特别是，在玻璃基板上沉积不同的纳米材料后，我们评估了它们对电路功能和几何形状的影响。由于 CNT 有核节点导致的几何限制允许神经元网络在控制网络几何形状的情况下生长，并探索其功能影响。在基础神经科学的各种应用中，