Although a link between the gut microbiota and alcohol-related liver diseases (ALDs) has previously been suggested, the causative effects of specific taxa and their functions have not been fully investigated to date. Here, we analyze the gut microbiota of 410 fecal samples from 212 Korean twins by using the Alcohol Use Disorders Identification Test (AUDIT) scales to adjust for host genetics. This analysis revealed a strong association between low AUDIT scores and the abundance of the butyrate-producing genus Roseburia. When Roseburia spp. are administered to ALD murine models, both hepatic steatosis and inflammation significantly improve regardless of bacterial viability. Specifically, the flagellin of R. intestinalis, possibly through Toll-like receptor 5 (TLR5) recognition, recovers gut barrier integrity through upregulation of the tight junction protein Occludin and helps to restore the gut microbiota through elevated expression of IL-22 and REG3γ. Our study demonstrates that Roseburia spp. improve the gut ecosystem and prevent leaky gut, leading to ameliorated ALDs.

中文翻译：

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玫瑰花属 与人类饮酒及其管理相关的丰度协会改善了小鼠的酒精性脂肪肝。

尽管以前已经提出了肠道菌群与酒精相关的肝病（ALDs）之间的联系，但迄今为止尚未完全研究特定分类群及其功能的致病作用。在这里，我们使用酒精使用障碍识别测试（AUDIT）量表对宿主遗传学进行了调整，分析了212名韩国双胞胎中410名粪便样品的肠道菌群。这项分析表明，较低的AUDIT分数与产生丁酸盐的Roseburia属的丰富程度之间存在很强的联系。当玫瑰花属。将其用于ALD鼠模型，无论细菌生存力如何，肝脂肪变性和炎症都会明显改善。具体而言，可能是通过Toll样受体5（TLR5）识别而引起的R. intestinalis的鞭毛蛋白，通过上紧连接蛋白Occludin的上调恢复肠道屏障的完整性，并通过提高IL-22和REG3γ的表达来帮助恢复肠道菌群。我们的研究表明，玫瑰果属。改善肠道生态系统并防止肠道漏水，从而改善ALD。