Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically silent. Here, we describe a bispecific antibody approach to harness MerTK for targeted clearance without inducing proinflammatory cytokine release associated with Fcγ receptor engagement. We generated bispecific antibodies targeting live B cells or amyloid beta aggregates to demonstrate the feasibility and versatility of this new approach.

中文翻译：

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利用MerTK激动剂靶向治疗。

吞噬作用在稳态和病理条件下均起着重要作用。Fcγ受体介导的吞噬作用已被开发为基于抗体的疗法的整体机制。与Fcγ受体介导的吞噬作用不同，MerTK介导的吞噬清除作用在免疫学上是沉默的。在这里，我们描述了一种双特异性抗体方法，可利用MerTK进行有针对性的清除，而不会诱导与Fcγ受体参与相关的促炎性细胞因子释放。我们生成了针对活B细胞或淀粉样β聚集体的双特异性抗体，以证明这种新方法的可行性和多功能性。