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Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report.
BMC Veterinary Research ( IF 2.6 ) Pub Date : 2019-12-19 , DOI: 10.1186/s12917-019-2213-1
Masamichi Yamashita 1 , Tomohiro Osaki 1 , Yusuke Murahata 1 , Yuji Sunden 1 , Rinko Morita 2 , Tomohiro Imagawa 1 , Yoshiharu Okamoto 1
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BACKGROUND Inflammatory pseudotumours (IPTs) are distinctive lesions consisting of myofibroblastic spindle cells and a variety of inflammatory cells. The aetiology of IPTs is unknown. Reports of IPTs in veterinary medicine have been scarse. Moreover, only one case of intradural extramedullary IPT has been previously reported. In this report, we introduce the first known case of canine IPT, which occurred in the parenchyma of the spinal cord. CASE PRESENTATION A 10-year-old female Miniature Dachshund presented with a 2-month-long history of progressively worsening ataxia and tetraparesis. Neurological examination was consistent with a lesion involving the cervical spinal cord. Magnetic resonance imaging revealed an intradural space-occupying lesion in the region of the fourth cervical vertebra. Dorsal laminectomy and resection of the mass were performed. Histopathological examination revealed the proliferation of immature spindle cells (fibroblasts/myofibroblasts and glial cells) and a highly cellular mixture of neutrophils, macrophages and lymphocytic cells. The mass was located in the parenchyma of the spinal cord and was diagnosed as an IPT occurring in the parenchyma of the spinal cord. No causative pathogen was detected. The dog's symptoms improved, during the first month after surgery. However, neurological symptoms, such as laboured breathing and dysuria, subsequently worsened and the dog died 42 days after surgery. CONCLUSIONS The present study describes a canine case of IPT occurring in the parenchyma of the spinal cord. The diagnosis and determination of the site of the mass was difficult solely based on preoperative imaging in the present case. The outcome of this case was poorer than that observed in cases of canine extramedullary IPT and human intramedullary IPT, in which the patients exhibited recovery. The prognosis after surgical resection cannot be decided from the present case alone. However, patients should be monitored for potential serious complications and recurrence.

中文翻译:

小型腊肠犬髓内炎性假瘤的影像学和病理学发现:病例报告。

背景技术炎性假瘤(IPT)是由肌纤维母细胞纺锤体细胞和多种炎性细胞组成的独特病变。IPT的病因尚不清楚。兽药中IPT的报道很少。此外,先前仅报道了一种硬膜内髓外IPT病例。在本报告中,我们介绍了犬IPT的第一个已知病例,它发生在脊髓实质中。病例介绍一名10岁的小型腊肠狗,表现出共济失调和轻瘫的病情持续了2个月之久。神经系统检查与累及颈脊髓的病变一致。磁共振成像显示在第四颈椎区域内有硬膜内占位性病变。进行了背椎板切除术和肿块切除术。组织病理学检查显示未成熟纺锤体细胞(成纤维细胞/成肌纤维细胞和神经胶质细胞)的增殖以及嗜中性粒细胞,巨噬细胞和淋巴细胞的高度细胞混合物。该肿块位于脊髓实质中,并被诊断为发生在脊髓实质中的IPT。未检测到致病性病原体。在手术后的第一个月,狗的症状有所改善。但是,神经症状,如呼吸困难和排尿困难,随后加重,狗在手术后42天死亡。结论本研究描述了IPT犬的一例发生在脊髓实质中。仅在本例中,仅基于术前成像很难诊断和确定肿块部位。该病例的结果比在犬髓外IPT和人髓内IPT的病例中观察到的情况差,其中患者表现出恢复。不能仅根据本病例确定手术切除后的预后。但是,应监测患者潜在的严重并发症和复发。
更新日期:2019-12-19
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