BACKGROUND Fluorescein angiography is an important and frequently used diagnostic tool in ophthalmological practice. In this case report we describe a patient who experienced an anaphylactic reaction after the injection of fluorescein. Furthermore, we report an interference with laboratory testing by fluorescein in this patient and summarize the literature on this topic. CASE PRESENTATION An 86-year old Caucasian woman undergoing fluorescein angiography due to suspected peripapillary neovascularizations collapsed after the injection of fluorescein. The patient developed an anaphylactic reaction. With fluid resuscitation and oxygen therapy, the patient regained consciousness after a few minutes. The patient was admitted to the geriatric ward for observation, and routine blood and urine tests were performed. Urine protein concentration appeared to be falsely increased as a consequence of disturbance of the laboratory analysis by the presence of fluorescein. CONCLUSIONS Serious complications can occur with fluorescein angiography, such as an anaphylactic reaction. In the case of anaphylaxis appropriate supportive measures including the use of oxygen and epinephrine (e.g. EpiPen), should be available to prevent morbidity and mortality from this test. Furthermore, these potential complications should be taken into consideration when choosing the healthcare setting for fluorescein angiography, such as the immediate availability of an acute medical team. Several studies have demonstrated the interference of laboratory analyses by fluorescein. The majority of these studies were published 10 to 30 years ago. By presenting this case, the authors hope to bring renewed attention to this phenomenon among clinicians, as falsely increased or decreased laboratory values can result in unnecessary diagnostics and/or therapy.

中文翻译：

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静脉注射荧光素后对尿蛋白测量的全身反应和干扰。

背景技术荧光素血管造影术是眼科实践中重要且经常使用的诊断工具。在此病例报告中，我们描述了注射荧光素后出现过敏反应的患者。此外，我们报告了该患者对荧光素进行实验室测试的干扰，并总结了有关该主题的文献。病例介绍一名86岁的白人妇女由于怀疑在注入荧光素后周围乳头状新生血管破裂而接受了荧光素血管造影检查。病人出现了过敏反应。通过液体复苏和氧气疗法，患者在几分钟后恢复了意识。该患者被送往老年病房进行观察，并进行了常规血液和尿液检查。由于荧光素的存在干扰了实验室分析，尿蛋白浓度似乎错误地增加了。结论荧光素血管造影可发生严重的并发症，例如过敏反应。如果发生过敏反应，应采取适当的支持措施，包括使用氧气和肾上腺素（例如EpiPen），以防止该试验的发病率和死亡率。此外，在选择荧光素血管造影的医疗环境时，例如急诊医疗队的即时可用性，应考虑这些潜在的并发症。几项研究证明了荧光素对实验室分析的干扰。这些研究大多数发表于10至30年前。通过介绍这个案例，