An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions. We found a strong positive association, on population and individual levels, between seropositivity for antibodies against Ebola virus and the presence of Plasmodium parasites in the blood. According to a multiple regression model accounting for other key variables, antibodies against Ebola virus emerged as the strongest individual-level risk factor for acquiring malaria. Our results suggest that within-host interactions between malaria parasites and Ebola virus may underlie epidemiologic associations.

中文翻译：

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加蓬农村地区接触埃博拉病毒和感染疟疾寄生虫的风险。

疟疾和埃博拉病毒病患者的死亡风险之间存在关联，这表明恶性疟原虫寄生虫与埃博拉病毒之间在宿主内部发生相互作用。为了确定这种相互作用是否也可能影响获得任何一种感染的可能性，我们使用了来自加蓬农村的大型快照监测研究，以检验过去接触埃博拉病毒是否与疟原虫属感染有关。在非流行病期间。我们发现，在人群和个体水平上，抗埃博拉病毒抗体的血清阳性与血液中疟原虫寄生虫之间存在很强的正相关性。根据考虑了其他关键变量的多元回归模型，针对埃博拉病毒的抗体已成为获得疟疾的最强个体水平风险因素。