The endocannabinoid system (eCB) is a ubiquitous lipid signaling system composed of at least two receptors, their endogenous ligands, and the enzymes responsible for their synthesis and degradation. Within the brain, the eCB system is highly expressed in the hippocampus and controls basic biological processes, including neuronal proliferation, migration and differentiation, which are intimately linked with embryonal neurogenesis. Accumulated preclinical evidence has indicated that eCBs play a major role also in regulating adult neurogenesis. Increased cannabinoid receptor activity, either by increased eCB content or by pharmacological blockade of their degradation, produces neurogenic effects alongside rescue of phenotypes in animal models of different psychiatric and neurological disorders. Therefore, in the light of the higher therapeutic potential of adult neurogenesis compared to the embryonic one, here we sought to summarize the most recent evidence pointing towards a neurogenic role for eCBs in the adult brain, both under normal and pathological conditions.

中文翻译：

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内源性大麻素系统和成人神经发生：重点综述。

内源性大麻素系统（eCB）是一种普遍存在的脂质信号系统，由至少两个受体，其内源性配体和负责其合成和降解的酶组成。在大脑中，eCB系统在海马中高度表达，并控制基本的生物学过程，包括神经元增殖，迁移和分化，这些过程与胚胎神经发生密切相关。积累的临床前证据表明，eCB在调节成人神经发生中也起着重要作用。通过增加eCB含量或通过药理上的降解来提高大麻素受体的活性，可以在不同精神病学和神经病学动物模型中挽救表型，并产生神经源性作用。所以，