Severe anemia is a major cause of death by malaria. The loss of uninfected erythrocytes is an important contributor to malarial anemia; however, the mechanisms underlying this pathology are not well understood. Malaria-induced anemia is related to autoimmune antibodies against the membrane lipid phosphatidylserine (PS). In mice, these antibodies induce the clearance of uninfected erythrocytes after binding to PS exposed in their membrane. In human malaria patients there is a strong correlation between anemia and anti-PS antibodies. During malaria, anti-PS antibodies are produced by atypical B cells, whose levels correlate with the development of anemia in patients. Autoimmune responses, which are documented frequently in different infections, contribute to the pathogenesis of malaria by inducing the clearance of uninfected erythrocytes.

中文翻译：

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疟疾中的自身免疫性贫血。

严重贫血是疟疾致死的主要原因。未感染的红细胞的丢失是导致疟疾贫血的重要原因。然而，这种病理学的机制尚不清楚。疟疾引起的贫血与针对膜脂质磷脂酰丝氨酸（PS）的自身免疫抗体有关。在小鼠中，这些抗体与暴露在其膜上的PS结合后，会诱导未感染红细胞的清除。在人类疟疾患者中，贫血和抗PS抗体之间存在很强的相关性。疟疾期间，非典型B细胞产生抗PS抗体，其水平与患者贫血的发展相关。在不同感染中经常被记录的自身免疫反应通过诱导未感染红细胞的清除而促进了疟疾的发病。