Malaria infection during pregnancy is associated with adverse birth outcomes but underlying mechanisms are poorly understood. Here, we discuss the impact of malaria in pregnancy on three pathways that are important regulators of healthy pregnancy outcomes: L-arginine-nitric oxide biogenesis, complement activation, and the heme axis. These pathways are not mutually exclusive, and they collectively create a proinflammatory, antiangiogenic milieu at the maternal-fetal interface that interferes with placental function and development. We hypothesize that targeting these host-response pathways would mitigate the burden of adverse birth outcomes attributable to malaria in pregnancy.

中文翻译：

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妊娠和不良出生结局中的疟疾：新机制和治疗机会。

怀孕期间的疟疾感染与不良的出生结局有关，但对潜在的机制了解甚少。在这里，我们讨论了疟疾对怀孕三个因素的影响，这三个因素是健康怀孕结局的重要调节因素：L-精氨酸-一氧化氮的生物发生，补体激活和血红素轴。这些途径不是互相排斥的，它们共同在母胎界面产生促炎，抗血管生成的环境，从而干扰胎盘的功能和发育。我们假设针对这些宿主反应途径将减轻妊娠疟疾导致的不良出生结局负担。