BACKGROUND The purpose of this study is to explore the therapeutic effect of percutaneous kyphoplasty (PKP) combined with anti-osteoporosis drug, zoledronic acid, on postmenopausal women with osteoporotic vertebral compression fracture (OVCF) and to perform an analysis of postoperative bone cement leakage risk factors. METHODS A total of 112 OVCF patients, according to therapeutic regimens, were divided into control group (n = 52, treated with PKP) and observation group (n = 60, treated with PKP and zoledronic acid injection). RESULTS Postoperative tumor necrosis factor-α and interleukin-6 levels were significantly decreased in the two groups, compared with those before treatment (both P < 0.05); bone mineral density (BMD), serum bone gla protein (BGP), and vertebral height ratio of injured vertebrae were significantly increased, and procollagen type I N-terminal propeptide (PINP), Cobb angle, visual analogue scale/score (VAS), and Oswestry disability index (ODI) were significantly decreased compared with those before treatment (all P < 0.05). There were significantly higher changes in difference value of BMD, PINP, BGP, vertebral height ratio of injured vertebrae, Cobb angle, VAS, and ODI levels and significantly better therapeutic effect in the observation group than those in the control group (all P < 0.05). Multivariate logistic regression analysis showed that the use of zoledronic acid, vertebral height ratio of injured vertebrae, and ODI were independent factors affecting the therapeutic effect, and that the dosage of bone cement, and peripheral vertebrae wall damage were independent risk factors causing postoperative bone cement leakage. There were no significant differences in postoperative bone cement leakage rate between the two groups. CONCLUSIONS Peripheral vertebrae wall damage and the dosage of bone cement are independent risk factors causing bone cement leakage in OVCF patients treated with PKP. PKP combined with zoledronic acid has an improvement effect on the condition of postmenopausal women with OVCF and reduces the inflammation and pain in patients, which is beneficial to clinical treatment.

中文翻译：

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经皮椎体后凸成形术联合抗骨质疏松药对绝经后骨质疏松椎体压缩性骨折妇女的治疗效果及术后骨水泥渗漏危险因素分析：一项回顾性队列研究。

背景技术这项研究的目的是探讨经皮后凸成形术（PKP）联合抗骨质疏松药物唑来膦酸对绝经后骨质疏松性椎体压缩性骨折（OVCF）妇女的疗效，并进行术后骨水泥渗漏风险的分析因素。方法根据治疗方案，将112例OVCF患者分为对照组（n = 52，用PKP治疗）和观察组（n = 60，用PKP和唑来膦酸治疗）。结果与治疗前相比，两组患者术后肿瘤坏死因子-α和白细胞介素6水平明显降低（均P <0.05）。受伤的椎骨的骨矿物质密度（BMD），血清骨gla蛋白（BGP）和椎高比显着增加，与治疗前相比，前胶原I型N末端前肽（PINP），Cobb角，视觉模拟量表/评分（OSS）和Oswestry残疾指数（ODI）显着降低（所有P <0.05）。观察组的BMD，PINP，BGP，椎高比，Cobb角，VAS和ODI水平的差异值显着高于对照组，且治疗效果明显好于对照组（所有P <0.05 ）。多元逻辑回归分析表明，唑来膦酸的使用，椎骨受伤时的椎高比和ODI是影响治疗效果的独立因素，而骨水泥的剂量和周围椎骨壁损伤是导致术后骨水泥发生的独立危险因素。泄漏。两组术后骨水泥渗漏率无明显差异。结论PKP治疗的OVCF患者周围椎体壁损伤和骨水泥剂量是导致骨水泥渗漏的独立危险因素。PKP联合唑来膦酸对绝经后OVCF妇女的病情有改善作用，减轻患者的炎症和疼痛，有利于临床治疗。