Biphasic calcium phosphate (BCP) ceramics are the subject of much attention for use as bone replacement material. However, it remains a challenge to promote the degradation and osteoinductivity performances of BCP ceramics. In this work, novel BCP ceramic microspheres with good degradation and excellent osteoinductivity were prepared through high‐content strontium (Sr) doping. The in vitro results indicated that the Sr10‐BCP, Sr40‐BCP, and Sr80‐BCP microspheres all had their HA crystals partially transformed to the beta tricalcium phosphate phase following high‐temperature sintering because of Ca‐deficient HA formed by the partial substitution of Ca ions by Sr ions. In addition, the degradation rate was increased with the doping of increasing amounts of Sr. All prepared microspheres enhanced human bone marrow‐derived mesenchymal stem cells attachment and proliferation. Specifically, among these modified microspheres, the Sr40‐BCP microspheres showed the highest osteogenic potential. Furthermore, Sr40‐BCP and HA microspheres were implanted in a calvarial defect model of rat to evaluate the in vivo bone augmentation ability. The results indicated that Sr40‐BCP microspheres degraded more completely and significantly promoted new bone regeneration compared with HA microspheres. In conclusion, Sr40‐BCP microspheres have excellent potential for degradation and bone regeneration and are promising osteogenic materials.

中文翻译：

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锶取代的双相磷酸钙微球促进降解性能并增强骨再生。

双相磷酸钙 (BCP) 陶瓷作为骨替代材料备受关注。然而，促进 BCP 陶瓷的降解和骨诱导性能仍然是一个挑战。在这项工作中，通过高含量的锶 (Sr) 掺杂制备了具有良好降解性和优异骨诱导性的新型 BCP 陶瓷微球。体外结果表明，Sr10-BCP、Sr40-BCP 和 Sr80-BCP 微球的 HA 晶体在高温烧结后均部分转化为 β 磷酸三钙相，这是因为其部分取代形成了缺钙的 HA。 Ca 离子由 Sr 离子。此外，随着 Sr 掺杂量的增加，降解率也增加。所有制备的微球都增强了人骨髓间充质干细胞的附着和增殖。具体而言，在这些修饰的微球中，Sr40-BCP 微球显示出最高的成骨潜力。此外，将 Sr40-BCP 和 HA 微球植入大鼠颅骨缺损模型以评估体内骨增量能力。结果表明，与HA微球相比，Sr40-BCP微球降解更彻底，并显着促进新骨再生。总之，Sr40-BCP 微球具有良好的降解和骨再生潜力，是有前景的成骨材料。将 Sr40-BCP 和 HA 微球植入大鼠颅骨缺损模型以评估体内骨增量能力。结果表明，与HA微球相比，Sr40-BCP微球降解更彻底，并显着促进新骨再生。总之，Sr40-BCP 微球具有良好的降解和骨再生潜力，是有前景的成骨材料。将 Sr40-BCP 和 HA 微球植入大鼠颅骨缺损模型以评估体内骨增量能力。结果表明，与HA微球相比，Sr40-BCP微球降解更彻底，并显着促进新骨再生。总之，Sr40-BCP 微球具有良好的降解和骨再生潜力，是有前景的成骨材料。