A substrate dependent regio‐ and stereoselective domino hydroalkoxylation‐formal cycloaddition is described for the facile synthesis of linear as well as spirocyclic 1,4‐heterocycle‐fused chromenes. The developed hydroalkoxylation cascade offered a quick access to the [6‐6‐7‐6] tetracyclic framework of cytorhizhins B–D.

中文翻译：

---

多米诺加氢烷氧基化-[4 + 2]-环加成反应立体合成1,4-杂环稠合的二茂铁：快速获得Cytorhizhins B–D的[6-6-6-7-6]四环核

底物依赖的区域和立体选择性多米诺加氢烷氧基化形式的环加成反应可用于线性和螺环1,4-杂环稠合色烯的简便合成。发达的加氢烷氧基化级联反应提供了对[-6-6-7-6]胞嘧啶B–D四环构架的快速访问。