INTRODUCTION We performed a validation study at our institution of the Internatonal Union Against Cancer (UICC latest version of TNM Classification of Malignant Tumours Eighth Edition. METHODS Data was collected from Queensland Oncology Online (QOOL) registry of NSCLC or SCLC cases between 2000 and 2015 and validated against Queensland Integrated Lung Cancer Outcomes Project (QILCOP) registry using case identification number, first name, last name, and date of birth. Where data was available, cases were classified according to UICC TNM 7th edition stage groupings and then compared to the 8th edition groupings. Kaplan-Meier curves were plotted and log-rank of survival differences using SPSS version 25. RESULTS Of 3636 cases, 3352 and 1031 had complete clinical and pathological staging respectively. Median survival time was shown to reduce with increasing clinical stage; 7th edition (IA:88, IB:44, IIA:31, IIB:18, IIIA:15, IIIB:8, IV:5 months) vs 8th edition TNM stage (IA1: not reached, IA2:88, IA3:53, IB:56, IIA:36, IIB:22, IIIA:14, IIIB:9, IIIC:8, IVA:6, IVB:3; months). A similar overall pattern was reflected in the pathologic stage; 7th edition (IA:124, IB:110, IIA:48, IIB:42, IIIA:26, IIIB:31, IV:27 months) vs. 8th edition (IA1:not reached, IA2:122, IA3:125, IB:144, IIA:98, IIB:57, IIIA:31, IIIB:24, IVA:7 months). The log-rank test for survival curves was significant at p <0.001. CONCLUSIONS Our external validation study confirms the prognostic accuracy of the 8th edition TNM lung cancer classification. Our analyses also demonstrated that IIIB, IIIC and IVA stage groups showed similar survival outcomes, and suggests further research for refinement.

中文翻译：

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第八版TNM肺癌分期系统的验证；简短的报告

中位生存时间显示出随着临床分期的增加而减少；第 7 版（IA：88，IB：44，IIA：31，IIB：18，IIIA：15，IIIB：8，IV：5 个月）与第 8 版 TNM 阶段（IA1：未达到，IA2：88，IA3：53） ，IB：56，IIA：36，IIB：22，IIIA：14，IIIB：9，IIIC：8，IVA：6，IVB：3；月）。病理阶段反映了类似的总体模式；第 7 版（IA：124，IB：110，IIA：48，IIB：42，IIIA：26，IIIB：31，IV：27 个月）与第 8 版（IA1：未达到，IA2：122，IA3：125， IB：144，IIA：98，IIB：57，IIIA：31，IIIB：24，IVA：7 个月）。生存曲线的对数秩检验在 p <0.001 处显着。结论 我们的外部验证研究证实了第 8 版 TNM 肺癌分类的预后准确性。我们的分析还表明 IIIB、IIIC 和 IVA 阶段组显示出相似的生存结果，