Gliomas are the most prevalent primary tumors of the brain and spinal cord. Histologically, they share features of normal glial cells, but whether gliomas originate from normal glial cells, glial or neural precursors, stem cells, or other cell types remains a topic of investigation. The enhanced expression of inducible nitric oxide synthase (iNOS) has been reported as a hallmark of chemoresistance in gliomas, and several lines of evidence have reported that a decreased proliferation of glioma cells could be related to the selective inhibition of iNOS. This review aims to summarize the current understanding of iNOS expression and activity modulation in the regulation of glioma pathogenesis, along with compounds that could act as therapeutic agents against glioma.

中文翻译：

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将iNOS靶向作为治疗脑胶质瘤的重要策略。

神经胶质瘤是脑和脊髓中最普遍的原发性肿瘤。从组织学上讲，它们具有正常神经胶质细胞的特征，但是神经胶质瘤是否起源于正常神经胶质细胞，神经胶质或神经前体，干细胞或其他细胞类型仍然是研究的主题。据报道，诱导型一氧化氮合酶（iNOS）表达的增强是神经胶质瘤中化学抗药性的标志，并且有几条证据表明，神经胶质瘤细胞增殖的减少可能与iNOS的选择性抑制有关。这篇综述旨在总结目前对iNOS表达和活性调节在胶质瘤发病机理调控中的理解，以及可能用作抗胶质瘤治疗剂的化合物。