AIMS To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD). METHODS AND RESULTS This study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7-8 h per day, never/rarely insomnia, no snoring, and no frequent excessive daytime sleepiness. Weighted genetic risk scores of coronary heart disease (CHD) or stroke were calculated. During a median of 8.5 years of follow-up, we documented 7280 incident CVD cases including 4667 CHD and 2650 stroke cases. Compared to those with a sleep score of 0-1, participants with a score of 5 had a 35% (19-48%), 34% (22-44%), and 34% (25-42%) reduced risk of CVD, CHD, and stroke, respectively. Nearly 10% of cardiovascular events in this cohort could be attributed to poor sleep pattern. Participants with poor sleep pattern and high genetic risk showed the highest risk of CHD and stroke. CONCLUSION In this large prospective study, a healthy sleep pattern was associated with reduced risks of CVD, CHD, and stroke among participants with low, intermediate, or high genetic risk.

中文翻译：

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睡眠模式、遗传易感性和心血管疾病发生率：一项针对 385 292 名英国生物银行参与者的前瞻性研究

目的 量化睡眠行为和遗传易感性与心血管疾病 (CVD) 发病率的关联。方法和结果 这项研究包括来自英国生物银行的 385 292 名最初没有 CVD 的参与者。我们根据五个睡眠因素新创建了健康睡眠评分，并将低风险组定义为：早睡眠型、每天睡眠 7-8 小时、从不/很少失眠、不打鼾、白天不频繁过度嗜睡。计算冠心病（CHD）或中风的加权遗传风险评分。在平均 8.5 年的随访期间，我们记录了 7280 例 CVD 病例，其中包括 4667 例 CHD 和 2650 例中风病例。与睡眠得分为 0-1 的参与者相比，得分为 5 的参与者的睡眠风险分别降低了 35% (19-48%)、34% (22-44%) 和 34% (25-42%)。分别为 CVD、CHD 和中风。该队列中近 10% 的心血管事件可归因于不良的睡眠模式。睡眠模式不佳和遗传风险高的参与者患冠心病和中风的风险最高。结论 在这项大型前瞻性研究中，健康的睡眠模式与低、中或高遗传风险参与者的 CVD、CHD 和中风风险降低相关。