BACKGROUND Kidney transplantation (KT) is the most obvious method of treating a patient with end-stage renal disease. In the early stages of KT, urine production is considered a marker of successful reperfusion of the kidney after anastomosis. However, there is no clear conclusion about the relationship between initial urine output after KT and 1-year renal function. Thus, we investigated the factors that affect 1-year kidney function after KT, including urine output. METHODS This retrospective study investigated the relationship between urine output in the 3 days after KT and transplanted kidney prognosis after 1-year. In total, 291 patients (129 living-donor and 162 deceased-donor transplant recipients) were analyzed; 24-h urine volume per body weight (in kilograms) was measured for 3 days postoperatively. The estimated glomerular filtration rate (eGFR), determined by the Modification of Diet in Renal Disease algorithm, was used as an index of renal function. Patients were grouped according to eGFR at 1-year after KT: a good residual function group, eGFR ≥60, and a poor residual function group, eGFR < 60. RESULT Recipients' factors affecting 1-year eGFR include height (P = 0.03), weight (P = 0.00), and body mass index (P = 0.00). Donor factors affecting 1-year eGFR include age (P = 0.00) and number of human leukocyte antigen (HLA) mismatches (P = 0.00). The urine output for 3 days after KT (postoperative day 1; 2 and 3) was associated with 1-year eGFR in deceased-donor (P = 0.00; P = 0.00 and P = 0.01). And, postoperative urine output was associated with the occurrence of delayed graft function (area under curve (AUC) = 0.913; AUC = 0.984 and AUC = 0.944). CONCLUSION Although postoperative urine output alone is not enough to predict 1-year GFR, the incidence of delayed graft function can be predicted. Also, the appropriate urine output after KT may differ depending on the type of the transplanted kidney. TRIAL REGISTRATION Clinical Research Information Service of the Korea National Institute of Health in the Republic of Korea (KCT0003571).

中文翻译：

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术后尿量与一年移植肾功能之间关系的回顾性研究。

背景技术肾移植（KT）是治疗患有终末期肾病的患者的最明显的方法。在KT的早期，尿液生成被认为是吻合术后肾脏成功再灌注的标志。但是，关于KT后初始尿量与1年肾功能之间的关系，尚无明确结论。因此，我们调查了影响KT后1年肾脏功能的因素，包括尿量。方法这项回顾性研究调查了KT后3天内尿量与1年后移植肾预后之间的关系。总共分析了291例患者（129名活体捐献者和162名死者捐献者）。术后3天测量每小时24小时尿量（以千克为单位）。肾小球滤过率的估计值（eGFR）由肾脏疾病饮食的修改算法确定，用作肾功能指标。患者在KT后1年根据eGFR分组：残余功能良好的人群eGFR≥60，残余功能不良的人群eGFR <60。结果影响1年eGFR的接受者因素包括身高（P = 0.03） ，体重（P = 0.00）和体重指数（P = 0.00）。影响1年eGFR的供体因素包括年龄（P = 0.00）和人白细胞抗原（HLA）错配数（P = 0.00）。KT后3天（术后第1、2和3天）的尿量与已故供体的1年eGFR相关（P = 0.00； P = 0.00和P = 0.01）。而且，术后尿量与移植物功能延迟的发生有关（曲线下面积（AUC）= 0.913; AUC = 0。984和AUC = 0.944）。结论尽管仅术后尿量不足以预测1年GFR，但可以预测移植物功能延迟的发生率。同样，根据肾脏移植的类型，KT后适当的尿量可能会有所不同。试验注册韩国国立卫生研究院临床研究信息服务（KCT0003571）。