Selective laser melting (SLM) can produce complex hierarchical architectures paving the way for highly customisable biodegradable load-bearing bone scaffolds. For the first time, an in-depth analysis on the performance of SLM-manufactured iron-manganese bone scaffolds suitable for load-bearing applications is presented. Microstructural, mechanical, corrosion and biological characterisations were performed on SLM-manufactured iron-manganese scaffolds. The microstructure of the scaffold consisted primarily of γ-austenite, leading to high ductility. The mechanical properties of the scaffold were sufficient for load-bearing applications even after 28 days immersion in simulated body fluids. Corrosion tests showed that the corrosion rate was much higher than bulk pure iron, attributed to a combination of the manufacturing method, the addition of Mn to the alloy and the design of the scaffold. In vitro cell testing showed that the scaffold had good biocompatibility and viability towards mammalian cells. Furthermore, the presence of filopodia showed good osteoblast adhesion. In vivo analysis showed successful bone integration with the scaffold, with new bone formation observed after 4 weeks of implantation. Overall the SLM manufactured porous Fe-35Mn implants showed promise for biodegradable load-bearing bone scaffold applications. STATEMENT OF SIGNIFICANCE: Biodegradable iron scaffolds are emerging as a promising treatment for critical bone defects. Within this field, selective laser melting (SLM) has become a popular method of manufacturing bespoke scaffolds. There is limited knowledge on SLM-manufactured iron bone scaffolds, and no knowledge on their application for load-bearing situations. The current manuscript is the first study to characterise SLM manufactured iron-manganese bone scaffolds for load-bearing applications and also the first study to perform In vivo testing on SLM produced biodegradable iron scaffolds. In this study, for the first time, the mechanical, corrosion and biological properties of an iron-manganese scaffold manufactured using SLM were investigated. In summary the SLM-manufactured porous iron-manganese implants displayed great potential for biodegradable load-bearing bone scaffolds.

中文翻译：

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可生物降解的多孔承重骨支架应用的增材制造的铁锰。

选择性激光熔化（SLM）可以产生复杂的层次结构，从而为高度可定制的可生物降解的承重骨支架铺平道路。首次对适用于承重应用的SLM制造的铁锰骨支架的性能进行了深入分析。在SLM制造的铁锰支架上进行了微观结构，机械，腐蚀和生物学表征。支架的微观结构主要由γ-奥氏体组成，从而具有较高的延展性。即使在模拟体液中浸泡28天后，该支架的机械性能也足以满足承重应用的需要。腐蚀测试表明，腐蚀速度比散装纯铁高得多，这归因于多种制造方法的结合，向合金中添加Mn和脚手架的设计。体外细胞测试表明该支架对哺乳动物细胞具有良好的生物相容性和生存力。此外，丝状伪足的存在显示出良好的成骨细胞粘附。体内分析显示与支架成功的骨整合，在植入4周后观察到新的骨形成。总体而言，SLM制造的多孔Fe-35Mn植入物显示出可生物降解的承重骨支架应用的前景。意义声明：可生物降解的铁支架正在成为治疗严重骨缺损的有前途的治疗方法。在该领域中，选择性激光熔化（SLM）已成为制造定制支架的一种流行方法。关于SLM制造的铁骨支架的知识很少，并且不了解其在承重情况下的应用。当前的手稿是第一个研究表征SLM生产的承重应用的铁锰骨支架的研究，也是第一个对SLM生产的可生物降解的铁支架进行体内测试的研究。在这项研究中，首次研究了使用SLM制造的铁锰支架的机械，腐蚀和生物学特性。总之，由SLM制造的多孔铁锰植入物在生物可降解承重骨支架方面显示出巨大潜力。在这项研究中，首次研究了使用SLM制造的铁锰支架的机械，腐蚀和生物学特性。总之，SLM制造的多孔铁锰植入物在生物可降解承重骨支架方面显示出巨大潜力。在这项研究中，首次研究了使用SLM制造的铁锰支架的机械，腐蚀和生物学特性。总之，SLM制造的多孔铁锰植入物在生物可降解承重骨支架方面显示出巨大潜力。