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Actin-based regulation of ciliogenesis - The long and the short of it.
Seminars in Cell & Developmental Biology ( IF 7.3 ) Pub Date : 2019-12-18 , DOI: 10.1016/j.semcdb.2019.12.005
John Copeland 1
Affiliation  

The primary cilia is found on the mammalian cell surface where it serves as an antenna for the reception and transmission of a variety of cellular signaling pathways. At its core the cilium is a microtubule-based organelle, but it is clear that its assembly and function are dependent upon the coordinated regulation of both actin and microtubule dynamics. In particular, the discovery that the centrosome is able to act as both a microtubule and actin organizing centre implies that both cytoskeletal networks are acting directly on the process of cilia assembly. In this review, we set our recent results with the formin FHDC1 in the context of current reports that show each stage of ciliogenesis is impacted by changes in actin dynamics. These include direct effects of actin filament assembly on basal body positioning, vesicle trafficking to and entry into the cilium, cilia length, cilia membrane organization and cilia-dependent signaling.

中文翻译:

基于肌动蛋白的纤毛形成调节-长与短。

在哺乳动物细胞表面发现了初级纤毛,它充当了接收和传输各种细胞信号通路的天线。纤毛的核心是基于微管的细胞器,但是很明显,其组装和功能取决于肌动蛋白和微管动力学的协调调节。特别地,中心体既可以充当微管又可以充当肌动蛋白组织中心的发现暗示着两个细胞骨架网络都直接作用于纤毛的组装过程。在这篇综述中,我们在最新报告的背景下使用了福尔明FHDC1设定了我们最近的结果,该报告显示纤毛发生的每个阶段都受到肌动蛋白动力学变化的影响。这些包括肌动蛋白丝组件对基础体位的直接影响,
更新日期:2019-12-18
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