BACKGROUND Prevalence rates for restless legs syndrome (RLS) and risk of Obstructive Sleep Apnea (OSA) in individuals with Neuromyelitis Optica Spectrum Disorder (NMOSD) and Clinically Isolated Syndrome (CIS) are unknown. The aims of the present study were to assess symptoms of RLS and self-assessed risks of OSA in individuals with NMOSD and CIS, to compare these prevalence rates with those of persons with multiple sclerosis (MS), and to associate RLS and OSA with expanded disability status scale (EDSS) scores, daytime sleepiness, fatigue, paresthesia, and medication. METHODS A total of 495 individuals (mean age = 34.92 years, 84.9% females) were assessed. Of these, 24 had NMOSD, 112 had CIS and 359 had MS. Trained neurologists ascertained individuals' neurological diagnoses, assessed their EDSS scores, and conducted a clinical interview to assess RLS. Additionally, participants completed questionnaires covering sociodemographic information, risks of snoring and OSA, daytime sleepiness, fatigue, paresthesia and medication. RESULTS Prevalence rates of RLS were 45.8% in NMOSD, 41.1% in CIS, and 28.7% in MS. Prevalence rates of self-assessed risks of OSA were 8.3% in NMOSD, 7.7% in CIS, and 7.8% in MS; these rates were not significantly different. Across the entire sample and within the diagnostic groups, RLS and OSA scores were unrelated to EDSS, daytime sleepiness, fatigue or medication. CONCLUSIONS Individuals with NMOSD, CIS and MS have high prevalence rates for RLS and self-assessed risks of obstructive sleep apnea syndrome (OSAS), which are unrelated to EDSS, daytime sleepiness, fatigue, paresthesia, or medication. Sleep issues should be monitored during routine check-ups for individuals with NMOSD and CIS.

中文翻译：

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多发性硬化症（MS），临床孤立综合征（CIS）和视神经脊髓炎性光谱障碍（NMOSD）患者的躁动腿综合征，自我评估的阻塞性睡眠呼吸暂停风险和白天嗜睡的患病率比较。

背景技术患有神经脊髓炎性视神经频谱疾病（NMOSD）和临床孤立综合症（CIS）的患者中不安腿综合征（RLS）的患病率和阻塞性睡眠呼吸暂停（OSA）的风险尚不清楚。本研究的目的是评估NMOSD和CIS患者的RLS症状和OSA自我评估的风险，将这些患病率与多发性硬化症（MS）患者的患病率进行比较，并将RLS和OSA与扩大残疾状态量表（EDSS）评分，白天嗜睡，疲劳，感觉异常和药物治疗。方法共有495人（平均年龄= 34.92岁，女性84.9％）进行了评估。其中，有24个具有NMOSD，有112个具有CIS，有359个具有MS。受过训练的神经科医生确定了个人的神经系统诊断，评估了他们的EDSS分数，并进行了临床访谈以评估RLS。此外，参与者还完成了有关社会人口统计学信息，打呼and和OSA风险，白天嗜睡，疲劳，感觉异常和药物治疗的问卷。结果NMOSD的RLS患病率为45.8％，CIS的患病率为41.1％，MS的患病率为28.7％。NMOSD的自我评估的OSA风险患病率为8.3％，独联体为7.7％，MS为7.8％。这些比率没有显着差异。在整个样本中以及在诊断组中，RLS和OSA评分与EDSS，白天嗜睡，疲劳或药物治疗无关。结论NMOSD，CIS和MS患者的RLS患病率较高，且自我评估的阻塞性睡眠呼吸暂停综合症（OSAS）风险与EDSS，白天嗜睡，疲劳，感觉异常或药物治疗无关。