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Selective slow-wave sleep suppression affects glucose tolerance and melatonin secretion. The role of sleep architecture.
Sleep Medicine ( IF 4.8 ) Pub Date : 2019-12-17 , DOI: 10.1016/j.sleep.2019.11.1254
Yu V Ukraintseva 1 , K M Liaukovich 1 , K A Saltykov 1 , D A Belov 2 , А N Nizhnik 2
Affiliation  

OBJECTIVES Our study aimed to assess the impact of one night of slow-wave sleep (SWS) suppression on glucose tolerance, and explore whether melatonin plays a role in glucose tolerance impairment after SWS suppression. METHODS In sum, 20 volunteers participated in two experimental sessions: a session with SWS suppression during one night's sleep and a session with a regular night's sleep (control). Each session included collecting seven salivary samples. The following morning, an oral glucose tolerance test (OGTT) was performed. RESULTS SWS suppression effects depended on the individual blood glucose response to the OGTT. During the control session, 'responders' (N = 11), already presented with low glucose tolerance, which further declined after SWS suppression. 'Non-responders' (N = 9) experienced high glucose tolerance in both conditions. Among the responders, SWS suppression led to an increase in melatonin at the moment of awakening, while in non-responders melatonin increased during the first half of the night. In both conditions, responders were characterized by a shorter total sleep time (TST) and less rapid eye movement (REM) sleep. During SWS suppression, they had more non-rapid eye movement (NREM) stage 1 and longer nocturnal wakefulness. Responders and non-responders showed a comparable amount of SWS. CONCLUSIONS This study highlights three key findings: first, SWS suppression leads to an increase in salivary melatonin; second, melatonin's effect on glucose tolerance depends on its secretion timing; and third, durations of REM sleep and nocturnal awakenings, appear to play an important role in melatonin secretion and glucose tolerance, indicating the potential clinical relevance of these findings for type 2 diabetes risk assessment.

中文翻译:

选择性的慢波睡眠抑制会影响葡萄糖耐量和褪黑激素分泌。睡眠架构的作用。

目的我们的研究旨在评估一晚慢波睡眠(SWS)抑制对葡萄糖耐量的影响,并探讨褪黑素是否在抑制SWS后对葡萄糖耐量减退中起作用。方法总的来说,有20名志愿者参加了两次实验性会议:一个晚上睡眠期间进行SWS抑制活动和一个规则晚上睡眠(对照)活动。每个环节包括收集七个唾液样本。第二天早晨,进行了口服葡萄糖耐量测试(OGTT)。结果SWS抑制作用取决于个人对OGTT的血糖反应。在控制期间,已经表现出低葡萄糖耐量的“响应者”(N = 11)在抑制SWS后进一步下降。“无反应者” (N = 9)在两种情况下均具有较高的葡萄糖耐量。在响应者中,SWS抑制导致唤醒时褪黑激素增加,而在无响应者中,前半夜褪黑激素增加。在这两种情况下,响应者的特征都是总睡眠时间(TST)较短,而眼球运动(REM)的快速睡眠较少。在抑制SWS期间,他们的第1阶段非快速眼动(NREM)较多,夜间觉醒时间更长。响应者和非响应者显示出相当数量的SWS。结论本研究突出了三个主要发现:首先,SWS抑制导致唾液褪黑激素增加;第二,SWS抑制导致唾液褪黑激素增加。其次,褪黑激素对葡萄糖耐量的影响取决于其分泌时机。第三,REM睡眠和夜间觉醒的持续时间,
更新日期:2019-12-18
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