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Combining In Vitro Data and Physiologically Based Kinetic Modeling Facilitates Reverse Dosimetry to Define In Vivo Dose-Response Curves for Bixin- and Crocetin-Induced Activation of PPARγ in Humans.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-01-07 , DOI: 10.1002/mnfr.201900880
Suparmi Suparmi 1, 2 , Laura de Haan 1 , Albertus Spenkelink 1 , Jochem Louisse 1 , Karsten Beekmann 1 , Ivonne M C M Rietjens 1
Affiliation  

It is investigated whether at realistic dietary intake bixin and crocetin could induce peroxisome proliferator‐activated receptor γ (PPARγ)‐mediated gene expression in humans using a combined in vitro–in silico approach.

中文翻译:

结合体外数据和基于生理学的动力学模型,可以方便地进行反向剂量测定,以定义Bixin和大黄素诱导的人体内PPARγ激活的体内剂量反应曲线。

通过结合体外-计算机模拟方法,研究了在现实饮食中联苯菊酯和藏红花青素是否可以诱导人体内过氧化物酶体增殖物激活受体γ(PPARγ)介导的基因表达。
更新日期:2020-01-07
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