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Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy.
Journal of Controlled Release ( IF 10.8 ) Pub Date : 2019-12-17 , DOI: 10.1016/j.jconrel.2019.12.028
Hong Wang 1 , Jie Li 1 , Yuqi Wang 2 , Xiang Gong 1 , Xiaoxuan Xu 1 , Jiaoying Wang 2 , Yaping Li 3 , Xianyi Sha 4 , Zhiwen Zhang 5
Affiliation  

Tumor hypoxia is a characteristic hallmark of malignant solid tumors, which remains an essential impediment to many current treatments like chemotherapy, radiotherapy, photodynamic therapy and immunotherapy, thereby leading to poor clinical prognosis after therapy. Rationally, modulating tumor hypoxia can be of great interest to augment the therapeutic efficacy of these treatments. In this review, we focus our discussion on current advances in nanoparticles-mediated tumor reoxygenation strategy for relieving tumor hypoxia to improve the therapeutic efficacy of versatile therapies. These nanoparticles can improve tumor oxygen levels via nanoparticles-mediated oxygen-carrying or oxygen-generating tactics to synergize the effectiveness of many current therapeutic modalities. Based on these considerable summaries and analyses, we propose some feasible perspectives on nanoparticles-based tumor reoxygenations to ameliorate the therapeutic outcomes.

中文翻译:

纳米粒子介导的复氧策略可缓解肿瘤缺氧,增强癌症治疗能力。

肿瘤缺氧是恶性实体瘤的特征性标志,其仍然是许多当前诸如化学疗法,放射疗法,光动力疗法和免疫疗法等治疗的主要障碍,从而导致治疗后临床预后不良。合理地,调节肿瘤缺氧对于增强这些治疗的治疗功效可能是非常重要的。在这篇综述中,我们集中讨论了纳米粒子介导的肿瘤复氧策略的当前进展,该策略可缓解肿瘤缺氧,从而改善通用疗法的疗效。这些纳米颗粒可通过纳米颗粒介导的载氧或产生氧的策略来协同多种当前治疗方式的有效性,从而改善肿瘤的氧水平。根据这些可观的总结和分析,
更新日期:2019-12-18
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