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Enhanced topical econazole antifungal efficacy by amine-functionalized silica nanoparticles
Bulletin of Materials Science ( IF 1.8 ) Pub Date : 2019-12-17 , DOI: 10.1007/s12034-019-1974-2 M Montazeri , M Razzaghi-Abyaneh , S A Nasrollahi , H Maibach , S Nafisi
Bulletin of Materials Science ( IF 1.8 ) Pub Date : 2019-12-17 , DOI: 10.1007/s12034-019-1974-2 M Montazeri , M Razzaghi-Abyaneh , S A Nasrollahi , H Maibach , S Nafisi
The present study aims at developing efficient econazole (ECO) platforms as topical creams for the treatment of fungal skin infections. The hexagonal mesoporous silica nanoparticle, known as MCM41, was synthesized and functionalized by aminopropyl groups (MCM41-NH2)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{2})$$\end{document}. Various ECO concentrations were loaded into MCM41 and MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} (MSNs); the optimized complexes with the highest entrapment efficiencies were characterized by X-ray powder diffraction, scanning electron microscopy (SEM) and gas-volumetric analysis (BET). SEM images showed a spherical shape of the parent nanoparticles—higher drug loading and incorporation into the nanoparticles were obtained by amino-functionalized MCM41. Cytotoxicity assays of MCM41 and MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} and the ECO inclusion complexes elucidated no toxicity to human dermal fibroblast cell lines. Enhanced antifungal activity against Candida albicans was observed for ECO/MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} compared with ECO/MCM41 and simple cream. No irritation was observed by the cream containing ECO/MSN application on white male rabbit skin after 72 h. MSNs were stable within 1 year storage. ECO-loaded silica nanoparticles can be considered for the development of reliable alternatives to ECO cream for the treatment of skin fungal infections.
中文翻译:
通过胺官能化二氧化硅纳米粒子增强局部益康唑抗真菌功效
本研究旨在开发有效的益康唑 (ECO) 平台作为治疗真菌性皮肤感染的外用乳膏。六方介孔二氧化硅纳米粒子,称为 MCM41,由氨基丙基(MCM41-NH2)合成和功能化(MCM41-NH2)\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{2})$$\end{document}。各种 ECO 浓度被加载到 MCM41 和 MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \ usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} (MSNs); 通过 X 射线粉末衍射、扫描电子显微镜 (SEM) 和气体体积分析 (BET) 对具有最高包封率的优化配合物进行了表征。SEM 图像显示母体纳米颗粒呈球形——通过氨基功能化的 MCM41 获得更高的载药量和纳米颗粒的掺入量。MCM41 和 MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek 的细胞毒性测定} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} 和 ECO 包合物表明对人真皮成纤维细胞系没有毒性. ECO/MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{ 观察到对白色念珠菌的抗真菌活性增强mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} 与 ECO/MCM41 和简单奶油相比. 72 小时后,在雄性白兔皮肤上涂抹含有 ECO/MSN 的乳膏没有观察到刺激。MSN 在 1 年内保持稳定。可以考虑将负载 ECO 的二氧化硅纳米粒子用于开发用于治疗皮肤真菌感染的 ECO 乳膏的可靠替代品。
更新日期:2019-12-17
中文翻译:
通过胺官能化二氧化硅纳米粒子增强局部益康唑抗真菌功效
本研究旨在开发有效的益康唑 (ECO) 平台作为治疗真菌性皮肤感染的外用乳膏。六方介孔二氧化硅纳米粒子,称为 MCM41,由氨基丙基(MCM41-NH2)合成和功能化(MCM41-NH2)\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{2})$$\end{document}。各种 ECO 浓度被加载到 MCM41 和 MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \ usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} (MSNs); 通过 X 射线粉末衍射、扫描电子显微镜 (SEM) 和气体体积分析 (BET) 对具有最高包封率的优化配合物进行了表征。SEM 图像显示母体纳米颗粒呈球形——通过氨基功能化的 MCM41 获得更高的载药量和纳米颗粒的掺入量。MCM41 和 MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek 的细胞毒性测定} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} 和 ECO 包合物表明对人真皮成纤维细胞系没有毒性. ECO/MCM41-NH2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{ 观察到对白色念珠菌的抗真菌活性增强mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {NH}_{{2}}$$\end{document} 与 ECO/MCM41 和简单奶油相比. 72 小时后,在雄性白兔皮肤上涂抹含有 ECO/MSN 的乳膏没有观察到刺激。MSN 在 1 年内保持稳定。可以考虑将负载 ECO 的二氧化硅纳米粒子用于开发用于治疗皮肤真菌感染的 ECO 乳膏的可靠替代品。