We report the case of a 20-year-old male complaining of sudden-onset, severe headaches, fever, chills, and generalized arthralgia. He had no symptoms of a respiratory tract infection. Blood examination revealed severe leukopenia and mild to moderate thrombocytopenia. Onset of symptoms was rapid, intense, and occurred only a few hours after routine tick-borne encephalitis (TBE) booster vaccine. The question of a relationship between booster vaccine administration and the febrile illness with bicytopenia was raised. A broad range of diagnostics excluded infections and other causes for bicytopenia. Symptoms resolved within a few days, and blood counts normalized within two weeks. Due to the close temporal relationship, a transient benign bicytopenia and febrile illness as a systemic reaction to TBE vaccination was assumed. Review of the literature and adverse event reporting systems suggest that this is a very rare reaction.

中文翻译：

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tick传脑炎加强疫苗接种后数小时内出现发热性疾病和双细胞减少症。

我们报道了一名20岁男性，抱怨突然发作，严重的头痛，发烧，发冷和全身性关节痛。他没有呼吸道感染的症状。血液检查发现严重的白细胞减少症和轻度至中度血小板减少症。症状发作迅速，剧烈，仅在常规tick传脑炎（TBE）加强疫苗后数小时出现。提出了加强疫苗接种与双细胞减少性发热性疾病之间的关系的问题。广泛的诊断方法排除了感染和其他原因引起的双血细胞减少症。几天后症状消失，两周内血液计数恢复正常。由于时间关系密切，因此认为暂时性良性双细胞减少症和高热疾病是对TBE疫苗的全身反应。