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The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer.
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2019-12-17 , DOI: 10.1039/c9cs00129h
Pui-Chi Lo 1 , M Salomé Rodríguez-Morgade , Ravindra K Pandey , Dennis K P Ng , Tomás Torres , Fabienne Dumoulin
Affiliation  

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.

中文翻译:

酞菁作为癌症光动力疗法的高级光敏剂的独特功能和前景。

酞菁类化合物显示出优异的光特性,使其成为癌症光动力疗法中必不可少的一类光敏剂。几种衍生物处于临床试验的各个阶段,并且一直在不断努力以提高其光动力学功效。为此,已经应用了各种策略来开发具有优化的光特性,双重治疗作用,肿瘤靶向特性和/或在肿瘤部位的特异性活化的高级酞菁。这篇教程综述重点介绍了酞菁作为癌症光动力疗法的先进光敏剂的优势和潜力。
更新日期:2020-02-24
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