Effect of high‐caloric nutrition on survival in amyotrophic lateral sclerosis,Annals of Neurology

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Effect of high‐caloric nutrition on survival in amyotrophic lateral sclerosis
Annals of Neurology ( IF 11.2 ) Pub Date : 2020-01-06 , DOI: 10.1002/ana.25661
Albert C Ludolph _{1,

2} , Johannes Dorst ₁ , Jens Dreyhaupt ₃ , Jochen H Weishaupt ₁ , Jan Kassubek ₁ , Ulrike Weiland ₁ , Thomas Meyer ₄ , Susanne Petri ₅ , Andreas Hermann _{6,

7} , Alexander Emmer ₈ , Julian Grosskreutz ₉ , Torsten Grehl ₁₀ , Daniel Zeller ₁₁ , Matthias Boentert ₁₂ , Bertold Schrank ₁₃ , Johannes Prudlo ₁₄ , Andrea S Winkler ₁₅ , Stanislav Gorbulev ₁₆ , Francesco Roselli ₁ , Joachim Schuster ₁ , Luc Dupuis ₁₇ ,

Affiliation

Department of Neurology, University of Ulm, Ulm, Germany.
German Center for Neurodegenerative Diseases, Ulm, Germany.
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Charité-Universitätsmedizin Berlin, Humboldt University of Berlin, Berlin, Germany.
Department of Neurology, Hannover Medical School, Hannover, Germany.
Department of Neurology, Dresden University of Technology and German Center for Neurodegenerative Diseases, Dresden, Germany.
Albrecht Kossel Translational Neurodegeneration Section, Department of Neurology, University of Rostock, Rostock, Germany.
Department of Neurology, Halle University Hospital, Halle/Saale, Germany.
Department of Neurology, Jena University Hospital, Jena, Germany.
Department of Neurology, Bergmannsheil University Hospital, Bochum, Germany.
Department of Neurology, University of Würzburg, Würzburg, Germany.
Department of Neurology, Institute of Translational Neurology, Münster University Hospital, Münster, Germany.
Department of Neurology, Deutsche Klinik für Diagnostik HELIOS Clinic of Wiesbaden, Wiesbaden, Germany.
Department of Neurology, University of Rostock, Rostock, Germany.
Department of Neurology, Technical University of Munich, Munich, Germany.
Interdisciplinary Center for Clinical Trials, Mainz University Medical Center, Mainz, Germany.
National Institute of Health and Medical Research, University of Strasbourg, Strasbourg, France.

Weight loss has been identified as a negative prognostic factor in amyotrophic lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases survival. Therefore, we sought to evaluate the efficacy of a high‐caloric fatty diet (HCFD) for increasing survival.

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