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UniprotR: Retrieving and visualizing protein sequence and functional information from Universal Protein Resource (UniProt knowledgebase).
Journal of Proteomics ( IF 3.3 ) Pub Date : 2019-12-14 , DOI: 10.1016/j.jprot.2019.103613
Mohamed Soudy 1 , Ali Mostafa Anwar 1 , Eman Ali Ahmed 2 , Aya Osama 1 , Shahd Ezzeldin 1 , Sebaey Mahgoub 1 , Sameh Magdeldin 3
Affiliation  

UniprotR is a software package designed to easily retrieve, cluster and visualize protein data from UniProt knowledgebase (UniProtKB) using R language. The package is implemented mainly to process, parse and illustrate proteomics data in a handy and time-saving approach allowing researchers to summarize all required protein information available at UniProtKB in a readable data frame, Excel CSV file, and/or graphical output. UniprotR generates a set of graphics including gene ontology, chromosomal location, protein scoring and status, protein networking, sequence phylogenetic tree, and physicochemical properties. In addition, the package supports clustering of proteins based on primary gene name or chromosomal location, facilitating additional downstream analysis. SIGNIFICANCE: In this work, we implemented a robust package for retrieving and visualizing information from multiple sources such UniProtKB, SWISS-MODEL, and STRING. UniprotR Contains functions that enable retrieving and cluster data in a handy way and visualize data in publishable graphs to facilitate researcher's work and fulfill their needs. UniprotR will aid in saving time for downstream data analysis instead of manual time consuming data analysis. AVAILABILITY AND IMPLEMENTATION: UniprotR released as free open source code under the license of GPLv3, and available in CRAN (The Comprehensive R Archive Network) and GitHub. (https://cran.r-project.org/web/packages/UniprotR/index.html). (https://github.com/Proteomicslab57357/UniprotR).

中文翻译:

UniprotR:从通用蛋白质资源(UniProt知识库)中检索和可视化蛋白质序列和功能信息。

UniprotR是一个软件包,旨在使用R语言从UniProt知识库(UniProtKB)轻松检索,聚类和可视化蛋白质数据。该软件包主要用于方便,省时的方法来处理,解析和说明蛋白质组学数据,使研究人员可以在可读数据框,Excel CSV文件和/或图形输出中汇总UniProtKB上所有必需的蛋白质信息。UniprotR生成一组图形,包括基因本体,染色体位置,蛋白质评分和状态,蛋白质网络,序列系统树和理化特性。此外,该软件包还支持基于一级基因名称或染色体位置的蛋白质聚类,从而有助于进行其他下游分析。意义:在这项工作中,我们实施了一个强大的程序包,用于从UniProtKB,SWISS-MODEL和STRING等多个来源检索和可视化信息。UniprotR包含的功能可以方便地检索和聚类数据,并以可发布的图形显示数据,以方便研究人员的工作并满足他们的需求。UniprotR将帮助节省下游数据分析的时间,而不是手动的费时的数据分析。可用性和实现:UniprotR是GPLv3许可下的免费开放源代码发布,可在CRAN(综合R存档网络)和GitHub中获得。(https://cran.r-project.org/web/packages/UniprotR/index.html)。(https://github.com/Proteomicslab57357/UniprotR)。UniprotR包含的功能可以方便地检索和聚类数据,并以可发布的图形显示数据,以方便研究人员的工作并满足他们的需求。UniprotR将帮助节省下游数据分析的时间,而不是手动的费时的数据分析。可用性和实现:UniprotR是GPLv3许可下的免费开放源代码发布,可在CRAN(综合R存档网络)和GitHub中获得。(https://cran.r-project.org/web/packages/UniprotR/index.html)。(https://github.com/Proteomicslab57357/UniprotR)。UniprotR包含的功能可以方便地检索和聚类数据,并以可发布的图形显示数据,以方便研究人员的工作并满足他们的需求。UniprotR将帮助节省下游数据分析的时间,而不是手动的费时的数据分析。可用性和实现:UniprotR是GPLv3许可下的免费开放源代码发布,可在CRAN(综合R存档网络)和GitHub中获得。(https://cran.r-project.org/web/packages/UniprotR/index.html)。(https://github.com/Proteomicslab57357/UniprotR)。UniprotR在GPLv3的许可下作为免费开放源代码发布,可在CRAN(综合R存档网络)和GitHub中获得。(https://cran.r-project.org/web/packages/UniprotR/index.html)。(https://github.com/Proteomicslab57357/UniprotR)。UniprotR在GPLv3的许可下作为免费开放源代码发布,可在CRAN(综合R存档网络)和GitHub中获得。(https://cran.r-project.org/web/packages/UniprotR/index.html)。(https://github.com/Proteomicslab57357/UniprotR)。
更新日期:2019-12-17
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