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Primary Cilia and Brain Wiring, Connecting the Dots.
Developmental Cell ( IF 11.8 ) Pub Date : 2019-12-16 , DOI: 10.1016/j.devcel.2019.11.017
Qiong Song 1 , Joseph G Gleeson 2
Affiliation  

Primary cilia function as cellular signaling hubs, integrating multiple signaling pathways. Patients with the ciliopathy Joubert syndrome have been suggested to have axonal tract defects. In this issue of Developmental Cell, Guo et al. (2019) demonstrate a ciliary signaling requirement for axonal tract development and connectivity through dysregulated PI3K/AKT/ACIII signaling.

中文翻译:

初级纤毛和大脑布线,连接点。

原发纤毛起细胞信号传导枢纽的作用,整合了多种信号传导途径。患有睫状体Joubert综合征的患者已被建议患有轴索缺陷。在本期《发育细胞》中,Guo等人。(2019)证明了PI3K / AKT / ACIII信号传导失调对轴突的发育和连通性具有睫状信号传导的要求。
更新日期:2019-12-17
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