The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural complexity. Reconstituting the pathways of these compounds in heterologous hosts is a promising solution; however, requires the complete elucidation of the biosynthetic genes involved and extensive metabolic engineering to optimise enzyme activity and metabolic flux. This review describes the current strategies and recent advancements in the production of these valuable therapeutic compounds, and highlights plant-derived immunomodulators as an emerging class of anti-cancer agents.

中文翻译：

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超越半合成青蒿素：植物来源的抗癌药物的代谢工程。

鉴于其生物利用度低和结构复杂，植物来源的抗癌化合物的发现和供应仍然具有挑战性。在异源宿主中重建这些化合物的途径是一个有前途的解决方案；然而，需要彻底阐明所涉及的生物合成基因和广泛的代谢工程以优化酶活性和代谢通量。这篇综述描述了这些有价值的治疗性化合物的生产中的当前策略和最新进展，并着重介绍了植物来源的免疫调节剂作为一类新兴的抗癌剂。