Journal of Functional Foods ( IF 5.6 ) Pub Date : 2019-12-13 , DOI: 10.1016/j.jff.2019.103731 Kuikui Li , Huan Qi , Qishun Liu , Tang Li , Wei Chen , Shuguang Li , Hai-long Piao , Heng Yin
Konjac glucomannan is safely and widely used in the functional food industry. Compared with glucomannan, glucomannan oligosaccharides have higher water solubility making them easier to absorb and utilize. These oligosaccharides are also associated with many biological activities. A novel glucomannan hydrolase PpGluA with high activity and substrate specificity which releases a series of konjac glucomannan oligosaccharides having DP 2–9 is described here. Selenium is one of the essential trace elements for humans. The selenium-modified glucomannan oligosaccharides were prepared by the sodium selenite-nitric acid method for the first time. Antitumor activity studies demonstrated that selenium-modified glucomannan oligosaccharides had better activity than inorganic sodium selenite and glucomannan oligosaccharides and inhibited tumor by inducing apoptosis through the mitochondrial pathway. This study suggests that selenium-modified glucomannan oligosaccharides may be have potential as a new functional food for inhibition of tumors.
中文翻译:
硒修饰的葡甘露聚糖低聚糖的制备及其抗肿瘤活性
魔芋葡甘露聚糖在功能性食品工业中被安全且广泛地使用。与葡甘露聚糖相比,葡甘露聚糖寡糖具有更高的水溶性,使其更易于吸收和利用。这些寡糖也与许多生物学活性有关。一种新颖的葡甘露聚糖水解酶PP本文描述了具有高活性和底物特异性的GluA,它可释放出一系列具有DP 2–9的魔芋葡甘露聚糖低聚糖。硒是人类必需的微量元素之一。硒修饰的葡甘露聚糖低聚糖是通过亚硒酸钠-硝酸法首次制备的。抗肿瘤活性研究表明,硒修饰的葡甘露聚糖寡糖比无机亚硒酸钠和葡甘露聚糖寡糖具有更好的活性,并通过线粒体途径诱导细胞凋亡来抑制肿瘤。这项研究表明,硒修饰的葡甘露聚糖低聚糖可能具有潜在的抑制肿瘤的新功能。