Chiral separation remains a very important topic in different fields of analytical chemistry such as pharmaceutical, agrochemical, environmental and food analysis. Over the last 20 years, various chiral monoliths, based on chiral selectors such as cyclodextrins and their derivatives, polysaccharide derivatives, proteins, antibiotics, chiral ligands, cinchona alkaloids and amino acid derivatives, as well as molecularly imprinted polymers, have been developed for the enantioseparation of a wide range of analytes. The present review summarizes the recent developments of monolithic chiral stationary phases (CSPs) with particular emphasis on their classification and preparation. The major challenges and future prospects of monolithic CSPs are also briefly discussed.

在药物，农业化学，环境和食品分析等分析化学的不同领域中，手性分离仍然是一个非常重要的主题。在过去的20年中，已开发出多种基于手性选择剂的手性整料，例如环糊精及其衍生物，多糖衍生物，蛋白质，抗生素，手性配体，金鸡纳生物碱和氨基酸衍生物，以及分子印迹聚合物。多种分析物的对映体分离。本综述总结了整体手性固定相（CSP）的最新发展，特别强调了它们的分类和制备。还简要讨论了整体式CSP的主要挑战和未来前景。