The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.

中文翻译：

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Meridianin D 类似物具有针对耻垢分枝杆菌的抗生物膜活性

细菌生物膜的形成显着降低抗生素治疗的功效。在此，我们研究了天然产物 meridianin D 的抗生物膜特性以及​​针对耻垢分枝杆菌的类似物库。结果，我们发现了几种能够抑制和分散耻垢分枝杆菌生物膜的类似物。